C3N-02919
— · cohortA4
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortA4
- subtype
- cohortA4
- age_years
- 57.908282
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.220
- PROTEIN_SECRETION+0.210
- CHOLESTEROL_HOMEOSTASIS+0.160
- MITOTIC_SPINDLE+0.160
- ANDROGEN_RESPONSE+0.150
- G2M_CHECKPOINT+0.150
- E2F_TARGETS+0.050
- BILE_ACID_METABOLISM+0.040
- DNA_REPAIR+0.040
- PI3K_AKT_MTOR_SIGNALING+0.010
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.400
- TNFA_SIGNALING_VIA_NFKB-0.350
- MYC_TARGETS_V1-0.320
- MYC_TARGETS_V2-0.310
- OXIDATIVE_PHOSPHORYLATION-0.310
- APICAL_SURFACE-0.290
- P53_PATHWAY-0.270
- PANCREAS_BETA_CELLS-0.270
- IL6_JAK_STAT3_SIGNALING-0.260
- INTERFERON_ALPHA_RESPONSE-0.260
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG13 | — | — | 0.843 |
| 2 | MNG214 | — | — | 0.827 |
| 3 | MNG352 | — | — | 0.801 |
| 4 | SRR8752376 | — | — | 0.792 |
| 5 | TCGA-A7-A13G-01A-11R-A13Q-07 | — | D | 0.792 |
| 6 | MDT-AP-2885 | Med | Medulloblastoma | 0.791 |
| 7 | TCGA-GU-A42P-01A-11R-A23W-07 | — | — | 0.791 |
| 8 | SRR934733 | — | — | 0.784 |
| 9 | C3N-00559 | — | cohortA1 | 0.784 |
| 10 | SJEPD030097_D2.RNA-Seq | EPN | Spinal EPN | 0.768 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.220 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.210 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.160 | Remibrutinib | — uncovered |
| MITOTIC_SPINDLE | 0.160 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.150 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.150 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.050 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.040 | Idelalisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.010 | Inavolisib | — uncovered |