MNG13
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- SPERMATOGENESIS+0.313
- PROTEIN_SECRETION+0.177
- G2M_CHECKPOINT+0.158
- BILE_ACID_METABOLISM+0.098
- MITOTIC_SPINDLE+0.093
- E2F_TARGETS+0.073
- KRAS_SIGNALING_DN+0.064
- ESTROGEN_RESPONSE_EARLY+0.039
- ESTROGEN_RESPONSE_LATE+0.020
- NOTCH_SIGNALING+0.016
Top 10 suppressed
- MYC_TARGETS_V2-0.514
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.427
- ALLOGRAFT_REJECTION-0.389
- OXIDATIVE_PHOSPHORYLATION-0.383
- IL6_JAK_STAT3_SIGNALING-0.378
- MYC_TARGETS_V1-0.371
- TNFA_SIGNALING_VIA_NFKB-0.361
- ANGIOGENESIS-0.341
- UV_RESPONSE_UP-0.326
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.309
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG214 | — | — | 0.890 |
| 2 | SRR627429 | GTEX | — | 0.846 |
| 3 | C3N-02919 | — | cohortA4 | 0.843 |
| 4 | SRR627451 | GTEX | — | 0.842 |
| 5 | TCGA-ZF-AA4X-01A-11R-A38B-07 | — | — | 0.835 |
| 6 | SRR33346951 | — | — | 0.835 |
| 7 | MDT-AP-2885 | Med | Medulloblastoma | 0.834 |
| 8 | MNG899 | — | — | 0.826 |
| 9 | C3N-00199 | — | cohortA1 | 0.825 |
| 10 | TCGA-LT-A5Z6-01A-11R-A28M-07 | — | — | 0.822 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| SPERMATOGENESIS | 0.313 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.177 | Remibrutinib | — uncovered |
| G2M_CHECKPOINT | 0.158 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.098 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.093 | Inavolisib | — uncovered |
| E2F_TARGETS | 0.073 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.064 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.039 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.020 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.016 | Inavolisib | — uncovered |
| PEROXISOME | 0.003 | Idelalisib | — uncovered |