eea52742.e0f3.48e7.87b0.14afc03a5046
— · cohortMD2
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortMD2
- subtype
- cohortMD2
- age_years
- 57
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- E2F_TARGETS+0.330
- G2M_CHECKPOINT+0.220
- INTERFERON_ALPHA_RESPONSE+0.220
- MITOTIC_SPINDLE+0.190
- DNA_REPAIR+0.150
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.070
- MYC_TARGETS_V1+0.050
- NOTCH_SIGNALING+0.050
- COMPLEMENT+0.040
- GLYCOLYSIS+0.040
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.440
- ESTROGEN_RESPONSE_EARLY-0.360
- CHOLESTEROL_HOMEOSTASIS-0.350
- ESTROGEN_RESPONSE_LATE-0.340
- OXIDATIVE_PHOSPHORYLATION-0.340
- UNFOLDED_PROTEIN_RESPONSE-0.340
- ADIPOGENESIS-0.330
- FATTY_ACID_METABOLISM-0.330
- MTORC1_SIGNALING-0.330
- ANDROGEN_RESPONSE-0.290
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR6013553 | — | cohortA3 | 0.806 |
| 2 | MNG357 | — | — | 0.798 |
| 3 | SRR1313133 | — | D | 0.772 |
| 4 | BS_9FHSNVS0 | ATRT | — | 0.747 |
| 5 | SRR8613722 | — | E | 0.736 |
| 6 | c01b5135.b754.4c57.a81d.68a951803fab | — | cohortMD1 | 0.735 |
| 7 | MNG182 | — | — | 0.732 |
| 8 | TCGA-98-A53I-01A-31R-A262-07 | — | cohortSQ2 | 0.726 |
| 9 | 83486 | EPN | Supratentorial EPN | 0.720 |
| 10 | SAMN03290905 | — | — | 0.719 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| E2F_TARGETS | 0.330 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.220 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.220 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.190 | Inavolisib | — uncovered |
| DNA_REPAIR | 0.150 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.070 | Inavolisib | — uncovered |
| MYC_TARGETS_V1 | 0.050 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.050 | Inavolisib | — uncovered |
| COMPLEMENT | 0.040 | Inavolisib | — uncovered |
| GLYCOLYSIS | 0.040 | Inavolisib | — uncovered |