ERR2278876

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b77c15a4-e4d9-5111-99c1-6f084b2fc501

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: —

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

KRAS_SIGNALING_DN+0.220
PANCREAS_BETA_CELLS+0.210
BILE_ACID_METABOLISM+0.070
PEROXISOME+0.060
ESTROGEN_RESPONSE_EARLY+0.010
APICAL_SURFACE+0.000
SPERMATOGENESIS-0.010
HEME_METABOLISM-0.030
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.030
ESTROGEN_RESPONSE_LATE-0.070

Top 10 suppressed

EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
ANGIOGENESIS-0.510
TNFA_SIGNALING_VIA_NFKB-0.490
G2M_CHECKPOINT-0.480
TGF_BETA_SIGNALING-0.470
E2F_TARGETS-0.460
INFLAMMATORY_RESPONSE-0.450
MTORC1_SIGNALING-0.410
PROTEIN_SECRETION-0.400
INTERFERON_GAMMA_RESPONSE-0.390

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SJEPD007_D.RNA-Seq medullo-epn-umap@date-based	EPN	Posterior Fossa EPN	0.932
2	aMVAC.P_005_TURBT_S223 bladder-landscape@3	—	—	0.914
3	TCGA-CF-A5U8-01A-11R-A28M-07 bladder-landscape@3	—	—	0.914
4	SRR650197 bladder-landscape@3	—	—	0.908
5	TCGA-E7-A7PW-01A-11R-A352-07 bladder-landscape@3	—	—	0.908
6	TCGA-XF-A8HG-01A-11R-A36F-07 bladder-landscape@3	—	—	0.907
7	MDT-AP-1161 medullo-epn-umap@date-based	Med	Medulloblastoma	0.907
8	MDT-AP-1131 medullo-epn-umap@date-based	Med	Medulloblastoma	0.901
9	SRR1367870 brain-umap@2	GTEX	—	0.901
10	TCGA-E9-A245-01A-22R-A16F-07 breast-umap@18	—	B	0.898

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
KRAS_SIGNALING_DN	0.220	Remibrutinib	— uncovered
PANCREAS_BETA_CELLS	0.210	Cobimetinib	— uncovered
BILE_ACID_METABOLISM	0.070	Inavolisib	— uncovered
PEROXISOME	0.060	Idelalisib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.010	Inavolisib	— uncovered