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TCGA-CF-A5U8-01A-11R-A28M-07

c6b32564-d6c2-5f3c-88fe-889bb3c844ae

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
13.10775296
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • OXIDATIVE_PHOSPHORYLATION+0.160
  • BILE_ACID_METABOLISM+0.120
  • KRAS_SIGNALING_DN+0.090
  • PANCREAS_BETA_CELLS+0.090
  • PEROXISOME+0.020
  • XENOBIOTIC_METABOLISM+0.010
  • REACTIVE_OXYGEN_SPECIES_PATHWAY+0.000
  • ADIPOGENESIS-0.040
  • FATTY_ACID_METABOLISM-0.050
  • ESTROGEN_RESPONSE_EARLY-0.100

Top 10 suppressed

  • E2F_TARGETS-0.650
  • G2M_CHECKPOINT-0.610
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.520
  • INFLAMMATORY_RESPONSE-0.490
  • MTORC1_SIGNALING-0.490
  • TNFA_SIGNALING_VIA_NFKB-0.480
  • MITOTIC_SPINDLE-0.460
  • IL6_JAK_STAT3_SIGNALING-0.450
  • ALLOGRAFT_REJECTION-0.430
  • UNFOLDED_PROTEIN_RESPONSE-0.380

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1ERR2278876
head-neck@1
0.914
2SRR12202450
bladder-landscape@3
0.911
3SRR8943008
bladder-landscape@3
0.911
4TCGA-BH-A0HN-01A-11R-A10U-07
breast-umap@18
B0.909
5SRR2016961
head-neck@1
0.906
6SRR1516072
bladder-landscape@3
0.904
7TCGA-CF-A27C-01A-11R-A16R-07
bladder-landscape@3
0.904
8R247
bladder-landscape@3
0.902
9TCGA-E9-A245-01A-22R-A16F-07
breast-umap@18
B0.901
10EPT0291
medullo-epn-umap@date-based
EPNEPN Tumor0.899

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 6 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
OXIDATIVE_PHOSPHORYLATION0.160Remibrutinib— uncovered
BILE_ACID_METABOLISM0.120Inavolisib— uncovered
KRAS_SIGNALING_DN0.090Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.090Cobimetinib— uncovered
PEROXISOME0.020Idelalisib— uncovered
XENOBIOTIC_METABOLISM0.010Inavolisib— uncovered