aMVAC.P_005_TURBT_S223
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.250
- SPERMATOGENESIS+0.150
- PANCREAS_BETA_CELLS+0.140
- BILE_ACID_METABOLISM+0.040
- XENOBIOTIC_METABOLISM+0.000
- MYOGENESIS-0.030
- MYC_TARGETS_V2-0.140
- HEME_METABOLISM-0.160
- FATTY_ACID_METABOLISM-0.180
- COAGULATION-0.190
Top 10 suppressed
- INTERFERON_GAMMA_RESPONSE-0.600
- INTERFERON_ALPHA_RESPONSE-0.580
- TGF_BETA_SIGNALING-0.570
- TNFA_SIGNALING_VIA_NFKB-0.540
- ALLOGRAFT_REJECTION-0.510
- ANDROGEN_RESPONSE-0.510
- INFLAMMATORY_RESPONSE-0.500
- PROTEIN_SECRETION-0.500
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.490
- G2M_CHECKPOINT-0.490
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-E7-A7PW-01A-11R-A352-07 | — | — | 0.954 |
| 2 | SRR1797247 | — | cohortSC | 0.953 |
| 3 | SRR8943038 | — | — | 0.952 |
| 4 | SRR1797231 | — | cohortSC | 0.944 |
| 5 | SRR25617918 | — | B | 0.942 |
| 6 | SRR23303752 | — | — | 0.941 |
| 7 | SRR1516072 | — | — | 0.939 |
| 8 | SRR1467813 | GTEX | — | 0.937 |
| 9 | TCGA-E9-A245-01A-22R-A16F-07 | — | B | 0.934 |
| 10 | SRR12202498 | — | — | 0.934 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.250 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.150 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.140 | Cobimetinib | — uncovered |
| BILE_ACID_METABOLISM | 0.040 | Inavolisib | — uncovered |