MNG687
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.545
- TGF_BETA_SIGNALING+0.485
- UV_RESPONSE_DN+0.368
- MITOTIC_SPINDLE+0.323
- WNT_BETA_CATENIN_SIGNALING+0.323
- UNFOLDED_PROTEIN_RESPONSE+0.320
- DNA_REPAIR+0.317
- NOTCH_SIGNALING+0.308
- ANDROGEN_RESPONSE+0.298
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.268
Top 10 suppressed
- INFLAMMATORY_RESPONSE-0.343
- INTERFERON_ALPHA_RESPONSE-0.340
- ALLOGRAFT_REJECTION-0.331
- KRAS_SIGNALING_DN-0.288
- INTERFERON_GAMMA_RESPONSE-0.287
- HYPOXIA-0.269
- E2F_TARGETS-0.255
- HEDGEHOG_SIGNALING-0.216
- ESTROGEN_RESPONSE_LATE-0.209
- GLYCOLYSIS-0.206
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MNG1043 | — | — | 0.788 |
| 2 | MNG1224 | — | — | 0.731 |
| 3 | SRR12202472 | — | — | 0.725 |
| 4 | MNG1034 | — | — | 0.713 |
| 5 | MNG975 | — | — | 0.699 |
| 6 | MNG458 | — | — | 0.693 |
| 7 | MNG1024 | — | — | 0.689 |
| 8 | DRR168549 | — | — | 0.688 |
| 9 | MNG1206 | — | — | 0.680 |
| 10 | MDT-AP-3299 | Med | Medulloblastoma | 0.678 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 25 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.545 | Remibrutinib | — uncovered |
| TGF_BETA_SIGNALING | 0.485 | Inavolisib | — uncovered |
| UV_RESPONSE_DN | 0.368 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.323 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.323 | Inavolisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.320 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.317 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.308 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.298 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.268 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.262 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.239 | Remibrutinib | — uncovered |
| UV_RESPONSE_UP | 0.174 | Idelalisib | — uncovered |
| APOPTOSIS | 0.144 | Idelalisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.116 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.111 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.105 | Remibrutinib | — uncovered |
| P53_PATHWAY | 0.099 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.080 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.066 | Inavolisib | — uncovered |