MNG823
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UNFOLDED_PROTEIN_RESPONSE+0.241
- DNA_REPAIR+0.237
- PROTEIN_SECRETION+0.219
- E2F_TARGETS+0.196
- WNT_BETA_CATENIN_SIGNALING+0.169
- G2M_CHECKPOINT+0.167
- MITOTIC_SPINDLE+0.148
- MYC_TARGETS_V2+0.111
- PEROXISOME+0.055
- MYC_TARGETS_V1+0.020
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.425
- ESTROGEN_RESPONSE_LATE-0.421
- HYPOXIA-0.412
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.407
- INFLAMMATORY_RESPONSE-0.405
- ESTROGEN_RESPONSE_EARLY-0.403
- APICAL_SURFACE-0.400
- HEDGEHOG_SIGNALING-0.395
- APOPTOSIS-0.378
- ANGIOGENESIS-0.372
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR655864 | GTEX | — | 0.900 |
| 2 | SRR661290 | GTEX | — | 0.881 |
| 3 | 7cd1f8af-7c1d-4a56-a617-b8debf493122 | — | — | 0.870 |
| 4 | s_150324_3b | EPN | Posterior Fossa EPN | 0.862 |
| 5 | TCGA-G2-A3VY-01A-11R-A22U-07 | — | — | 0.859 |
| 6 | SRR657325 | GTEX | — | 0.857 |
| 7 | MDT-AP-1193 | Med | Medulloblastoma | 0.856 |
| 8 | SRR1317323 | GTEX | — | 0.855 |
| 9 | BS_9V633J1X | medulloblastoma | — | 0.854 |
| 10 | SJEPD030097_D2.RNA-Seq | EPN | Spinal EPN | 0.854 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 12 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UNFOLDED_PROTEIN_RESPONSE | 0.241 | Idelalisib | — uncovered |
| DNA_REPAIR | 0.237 | Idelalisib | — uncovered |
| PROTEIN_SECRETION | 0.219 | Remibrutinib | — uncovered |
| E2F_TARGETS | 0.196 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.169 | Inavolisib | — uncovered |
| G2M_CHECKPOINT | 0.167 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.148 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.111 | Idelalisib | — uncovered |
| PEROXISOME | 0.055 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.020 | Inavolisib | — uncovered |
| PI3K_AKT_MTOR_SIGNALING | 0.015 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.014 | Inavolisib | — uncovered |