MBCProject_3946_T5A_RNA
— · C
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- C
- subtype
- C
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.700
- FATTY_ACID_METABOLISM+0.460
- PANCREAS_BETA_CELLS+0.450
- PROTEIN_SECRETION+0.320
- ADIPOGENESIS+0.300
- REACTIVE_OXYGEN_SPECIES_PATHWAY+0.300
- PEROXISOME+0.270
- XENOBIOTIC_METABOLISM+0.220
- BILE_ACID_METABOLISM+0.190
- MTORC1_SIGNALING+0.170
Top 10 suppressed
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.580
- TNFA_SIGNALING_VIA_NFKB-0.410
- ALLOGRAFT_REJECTION-0.400
- INTERFERON_ALPHA_RESPONSE-0.400
- INTERFERON_GAMMA_RESPONSE-0.400
- INFLAMMATORY_RESPONSE-0.380
- E2F_TARGETS-0.360
- TGF_BETA_SIGNALING-0.350
- WNT_BETA_CATENIN_SIGNALING-0.340
- IL6_JAK_STAT3_SIGNALING-0.330
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_3946_T5B_RNA | — | C | 0.954 |
| 2 | SRR8518189 | — | F | 0.886 |
| 3 | SRR8518211 | — | C | 0.872 |
| 4 | SRR1431183 | GTEX | — | 0.871 |
| 5 | TCGA-TN-A7HJ-01A-12R-A34R-07 | — | — | 0.870 |
| 6 | SRR4296070 | — | cohortA1 | 0.852 |
| 7 | SRR8943024 | — | — | 0.849 |
| 8 | SRR1471817 | GTEX | — | 0.848 |
| 9 | TCGA-B6-A0RO-01A-22R-A084-07 | — | C | 0.843 |
| 10 | 20070161.TNBC | — | F | 0.842 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 20 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.700 | Remibrutinib | — uncovered |
| FATTY_ACID_METABOLISM | 0.460 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.450 | Cobimetinib | — uncovered |
| PROTEIN_SECRETION | 0.320 | Remibrutinib | — uncovered |
| ADIPOGENESIS | 0.300 | Inavolisib | — uncovered |
| REACTIVE_OXYGEN_SPECIES_PATHWAY | 0.300 | Inavolisib | — uncovered |
| PEROXISOME | 0.270 | Idelalisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.220 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| MTORC1_SIGNALING | 0.170 | Inavolisib | — uncovered |
| ANDROGEN_RESPONSE | 0.160 | Inavolisib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.160 | Remibrutinib | — uncovered |
| GLYCOLYSIS | 0.130 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.130 | Temsirolimus | — uncovered |
| KRAS_SIGNALING_DN | 0.120 | Remibrutinib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.080 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.060 | Idelalisib | — uncovered |
| P53_PATHWAY | 0.030 | Idelalisib | — uncovered |
| NOTCH_SIGNALING | 0.020 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.010 | Idelalisib | — uncovered |