62454053-936d-4f19-8522-6219c47bdd1c
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 68
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- UV_RESPONSE_DN+0.310
- SPERMATOGENESIS+0.180
- PROTEIN_SECRETION+0.040
- KRAS_SIGNALING_DN+0.020
- ANDROGEN_RESPONSE+0.010
- MITOTIC_SPINDLE-0.010
- TGF_BETA_SIGNALING-0.040
- HEDGEHOG_SIGNALING-0.060
- KRAS_SIGNALING_UP-0.100
- BILE_ACID_METABOLISM-0.110
Top 10 suppressed
- OXIDATIVE_PHOSPHORYLATION-0.620
- MYC_TARGETS_V2-0.590
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.570
- INTERFERON_ALPHA_RESPONSE-0.520
- CHOLESTEROL_HOMEOSTASIS-0.510
- DNA_REPAIR-0.510
- MYC_TARGETS_V1-0.490
- MTORC1_SIGNALING-0.460
- P53_PATHWAY-0.460
- UV_RESPONSE_UP-0.460
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
7 twins match this tumor's tissue · 3 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | b8135e73-31c3-49af-b4da-a7ed5f28d68a | — | — | 0.985 |
| 2 | e356598b-7611-492a-98ed-ef2ec1b77b7a | — | — | 0.979 |
| 3 | ed8896f8-24ef-43a4-ace6-ed9353bd11c2 | — | — | 0.977 |
| 4 | TCGA-A7-A0DB-01C-02R-A277-07 | — | D | 0.975 |
| 5 | 69550f7f-5251-4657-863b-bd35d69c82c4 | — | — | 0.973 |
| 6 | d1447a31-64bb-4e70-ae50-eeff7a605f38 | — | — | 0.960 |
| 7 | SRR627429 | GTEX | — | 0.953 |
| 8 | SRR627462 | GTEX | — | 0.935 |
| 9 | SRR627451 | GTEX | — | 0.934 |
| 10 | TCGA-A7-A13D-01B-04R-A277-07 | — | D | 0.933 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| UV_RESPONSE_DN | 0.310 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.180 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.040 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |
| ANDROGEN_RESPONSE | 0.010 | Inavolisib | — uncovered |