SRR627429

GTEX

966301fa-1215-5eee-ab43-30a1eb21a713

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: GTEX
cancer_type_detailed: —
subtype: —
cancer_type: GTEX
sex: Female

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

SPERMATOGENESIS+0.193
UV_RESPONSE_DN+0.150
KRAS_SIGNALING_DN+0.121
MITOTIC_SPINDLE+0.107
G2M_CHECKPOINT+0.087
PROTEIN_SECRETION-0.013
PANCREAS_BETA_CELLS-0.078
ANDROGEN_RESPONSE-0.079
BILE_ACID_METABOLISM-0.088
APICAL_SURFACE-0.121

Top 10 suppressed

REACTIVE_OXYGEN_SPECIES_PATHWAY-0.527
OXIDATIVE_PHOSPHORYLATION-0.510
INTERFERON_ALPHA_RESPONSE-0.473
MYC_TARGETS_V2-0.452
MYC_TARGETS_V1-0.451
ADIPOGENESIS-0.443
TNFA_SIGNALING_VIA_NFKB-0.439
DNA_REPAIR-0.436
APOPTOSIS-0.426
UV_RESPONSE_UP-0.424

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR627451 brain-umap@2	GTEX	—	0.990
2	SRR627462 brain-umap@2	GTEX	—	0.986
3	62454053-936d-4f19-8522-6219c47bdd1c colon-landscapes@1	—	—	0.953
4	e356598b-7611-492a-98ed-ef2ec1b77b7a colon-landscapes@1	—	—	0.951
5	SRR627455 brain-umap@2	GTEX	—	0.949
6	ed8896f8-24ef-43a4-ace6-ed9353bd11c2 colon-landscapes@1	—	—	0.948
7	b8135e73-31c3-49af-b4da-a7ed5f28d68a colon-landscapes@1	—	—	0.941
8	SRR1455060 brain-umap@2	GTEX	—	0.936
9	SRR627299 brain-umap@2	GTEX	—	0.928
10	TCGA-A7-A0DB-01C-02R-A277-07 breast-umap@18	—	D	0.922

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 5 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
SPERMATOGENESIS	0.193	Inavolisib	— uncovered
UV_RESPONSE_DN	0.150	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.121	Remibrutinib	— uncovered
MITOTIC_SPINDLE	0.107	Inavolisib	— uncovered
G2M_CHECKPOINT	0.087	Inavolisib	— uncovered