Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_KPT2WPHW

Ganglioglioma

c5030d2e-3a86-5494-93a3-4a39483b6579

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Ganglioglioma
cancer_type_detailed
subtype
cancer_type
Ganglioglioma
overall_survival_months
3.876478318002628
age_years
0.992
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.499
  • PANCREAS_BETA_CELLS+0.426
  • SPERMATOGENESIS+0.360
  • HEDGEHOG_SIGNALING+0.247
  • MYOGENESIS+0.244
  • APICAL_SURFACE+0.194
  • ESTROGEN_RESPONSE_LATE+0.129
  • ESTROGEN_RESPONSE_EARLY+0.112
  • BILE_ACID_METABOLISM+0.103
  • APICAL_JUNCTION+0.089

Top 10 suppressed

  • MYC_TARGETS_V1-0.637
  • MYC_TARGETS_V2-0.617
  • DNA_REPAIR-0.557
  • E2F_TARGETS-0.553
  • UNFOLDED_PROTEIN_RESPONSE-0.552
  • INTERFERON_ALPHA_RESPONSE-0.546
  • INTERFERON_GAMMA_RESPONSE-0.534
  • PROTEIN_SECRETION-0.526
  • G2M_CHECKPOINT-0.502
  • OXIDATIVE_PHOSPHORYLATION-0.470

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

3 twins match this tumor's tissue · 7 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_C7N3J4NW
brain-umap@2
high-grade glioma0.984
2BS_K5802F84
brain-umap@2
pilocytic astrocytoma0.980
3BS_CQSAJ7BF
brain-umap@2
DNET0.976
4BS_92VDQ0NE
brain-umap@2
Ganglioglioma0.976
5BS_6MY8W3H0
brain-umap@2
DNET0.975
6BS_SM8VQFPD
brain-umap@2
DNET0.965
7BS_3T6X4BPC
brain-umap@2
DNET0.963
8BS_QV51J756
brain-umap@2
Ganglioglioma0.961
9BS_QC3XCE6X
brain-umap@2
low-grade glioma0.959
10BS_MF47B9ZW
brain-umap@2
Ganglioglioma0.958

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 13 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.499Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.426Cobimetinib— uncovered
SPERMATOGENESIS0.360Inavolisib— uncovered
HEDGEHOG_SIGNALING0.247Inavolisib— uncovered
MYOGENESIS0.244Inavolisib— uncovered
APICAL_SURFACE0.194Temsirolimus— uncovered
ESTROGEN_RESPONSE_LATE0.129Idelalisib— uncovered
ESTROGEN_RESPONSE_EARLY0.112Inavolisib— uncovered
BILE_ACID_METABOLISM0.103Inavolisib— uncovered
APICAL_JUNCTION0.089Inavolisib— uncovered
COAGULATION0.035Binimetinib— uncovered
UV_RESPONSE_DN0.021Inavolisib— uncovered
KRAS_SIGNALING_UP0.005Inavolisib— uncovered