Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_92VDQ0NE

Ganglioglioma

d0c88dda-b0d5-51f0-97f0-7af9309978c4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
Ganglioglioma
cancer_type_detailed
subtype
cancer_type
Ganglioglioma
overall_survival_months
359.1327201051248
age_years
2.54
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • KRAS_SIGNALING_DN+0.480
  • SPERMATOGENESIS+0.287
  • PANCREAS_BETA_CELLS+0.279
  • APICAL_SURFACE+0.263
  • MYOGENESIS+0.187
  • BILE_ACID_METABOLISM+0.135
  • HEDGEHOG_SIGNALING+0.124
  • ESTROGEN_RESPONSE_EARLY+0.088
  • ESTROGEN_RESPONSE_LATE+0.083
  • HEME_METABOLISM+0.042

Top 10 suppressed

  • MYC_TARGETS_V1-0.664
  • MYC_TARGETS_V2-0.630
  • E2F_TARGETS-0.590
  • DNA_REPAIR-0.581
  • UNFOLDED_PROTEIN_RESPONSE-0.578
  • G2M_CHECKPOINT-0.566
  • OXIDATIVE_PHOSPHORYLATION-0.508
  • INTERFERON_GAMMA_RESPONSE-0.445
  • MTORC1_SIGNALING-0.440
  • INTERFERON_ALPHA_RESPONSE-0.436

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

2 twins match this tumor's tissue · 8 come from a different tissue of origin ← cross-tissue dominant

#SampleCancer typeSubtypecos similarity
1BS_K5802F84
brain-umap@2
pilocytic astrocytoma0.981
2BS_CQSAJ7BF
brain-umap@2
DNET0.976
3BS_KPT2WPHW
brain-umap@2
Ganglioglioma0.976
4BS_ZR96A4FH
brain-umap@2
DNET0.964
5BS_QC3XCE6X
brain-umap@2
low-grade glioma0.963
6BS_QV51J756
brain-umap@2
Ganglioglioma0.962
7BS_C7N3J4NW
brain-umap@2
high-grade glioma0.962
8BS_JXNZYGCR
brain-umap@2
DNET0.962
9BS_6MY8W3H0
brain-umap@2
DNET0.959
10BS_0T17SY47
brain-umap@2
low-grade glioma0.957

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 10 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.480Remibrutinib— uncovered
SPERMATOGENESIS0.287Inavolisib— uncovered
PANCREAS_BETA_CELLS0.279Cobimetinib— uncovered
APICAL_SURFACE0.263Temsirolimus— uncovered
MYOGENESIS0.187Inavolisib— uncovered
BILE_ACID_METABOLISM0.135Inavolisib— uncovered
HEDGEHOG_SIGNALING0.124Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.088Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.083Idelalisib— uncovered
HEME_METABOLISM0.042Temsirolimus— uncovered