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SRR23303775

c57da88d-bbd4-5714-be0d-ecc296937b97

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • WNT_BETA_CATENIN_SIGNALING+0.030
  • KRAS_SIGNALING_DN-0.080
  • SPERMATOGENESIS-0.080
  • MITOTIC_SPINDLE-0.120
  • MYC_TARGETS_V2-0.160
  • HEME_METABOLISM-0.210
  • BILE_ACID_METABOLISM-0.260
  • NOTCH_SIGNALING-0.270
  • INTERFERON_ALPHA_RESPONSE-0.280
  • UV_RESPONSE_DN-0.280

Top 10 suppressed

  • ANGIOGENESIS-0.620
  • EPITHELIAL_MESENCHYMAL_TRANSITION-0.580
  • MYC_TARGETS_V1-0.550
  • MTORC1_SIGNALING-0.540
  • CHOLESTEROL_HOMEOSTASIS-0.530
  • IL6_JAK_STAT3_SIGNALING-0.520
  • TNFA_SIGNALING_VIA_NFKB-0.520
  • INFLAMMATORY_RESPONSE-0.510
  • OXIDATIVE_PHOSPHORYLATION-0.500
  • E2F_TARGETS-0.490

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR650134
bladder-landscape@3
0.963
2AUR-AFE5-TTM9-A-1-1-R-A742-41
breast-umap@18
D0.936
3SRR650166
bladder-landscape@3
0.934
4AUR-AERW-TTP1-B-1-0-R-A741-41
breast-umap@18
D0.929
5SRR650197
bladder-landscape@3
0.929
6SRR23303752
bladder-landscape@3
0.927
7SRR12696758
melanoma-umap@29
0.924
8SRR12696768
melanoma-umap@29
0.924
9SRR627299
brain-umap@2
GTEX0.923
10SRR1388504
brain-umap@2
GTEX0.922

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 1 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
WNT_BETA_CATENIN_SIGNALING0.030Inavolisib— uncovered