SRR1465114
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.380
- KRAS_SIGNALING_DN+0.329
- MYOGENESIS+0.239
- SPERMATOGENESIS+0.227
- FATTY_ACID_METABOLISM+0.210
- HEDGEHOG_SIGNALING+0.176
- BILE_ACID_METABOLISM+0.153
- PANCREAS_BETA_CELLS+0.136
- ADIPOGENESIS+0.120
- ESTROGEN_RESPONSE_LATE+0.114
Top 10 suppressed
- MYC_TARGETS_V2-0.482
- TNFA_SIGNALING_VIA_NFKB-0.472
- INTERFERON_ALPHA_RESPONSE-0.465
- INFLAMMATORY_RESPONSE-0.447
- IL6_JAK_STAT3_SIGNALING-0.441
- UNFOLDED_PROTEIN_RESPONSE-0.430
- MTORC1_SIGNALING-0.423
- INTERFERON_GAMMA_RESPONSE-0.420
- ANGIOGENESIS-0.414
- G2M_CHECKPOINT-0.413
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1498640 | GTEX | — | 0.953 |
| 2 | SRR1324431 | GTEX | — | 0.952 |
| 3 | SRR1374221 | GTEX | — | 0.949 |
| 4 | SRR1445347 | GTEX | — | 0.942 |
| 5 | SRR818418 | GTEX | — | 0.936 |
| 6 | SRR1312103 | GTEX | — | 0.933 |
| 7 | SRR818396 | GTEX | — | 0.933 |
| 8 | SRR1445408 | GTEX | — | 0.929 |
| 9 | SRR614647 | GTEX | — | 0.927 |
| 10 | SRR1329377 | GTEX | — | 0.927 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 13 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.380 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.329 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.239 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.227 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.210 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.176 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.153 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.136 | Cobimetinib | — uncovered |
| ADIPOGENESIS | 0.120 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_LATE | 0.114 | Idelalisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.053 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.042 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.040 | Inavolisib | — uncovered |