SRR1394566
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.475
- KRAS_SIGNALING_DN+0.385
- SPERMATOGENESIS+0.367
- COAGULATION+0.145
- MYOGENESIS+0.115
- ALLOGRAFT_REJECTION+0.098
- HEDGEHOG_SIGNALING+0.090
- BILE_ACID_METABOLISM+0.009
- APICAL_SURFACE-0.003
- KRAS_SIGNALING_UP-0.009
Top 10 suppressed
- MYC_TARGETS_V1-0.570
- TGF_BETA_SIGNALING-0.544
- MITOTIC_SPINDLE-0.514
- UNFOLDED_PROTEIN_RESPONSE-0.491
- OXIDATIVE_PHOSPHORYLATION-0.455
- DNA_REPAIR-0.453
- MYC_TARGETS_V2-0.453
- ANDROGEN_RESPONSE-0.442
- PROTEIN_SECRETION-0.432
- G2M_CHECKPOINT-0.425
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-DK-A1A7-01A-11R-A13Y-07 | — | — | 0.973 |
| 2 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.971 |
| 3 | SRR1417111 | GTEX | — | 0.967 |
| 4 | MDT-AP-0706 | Med | Medulloblastoma | 0.961 |
| 5 | msclc569389_S35.txt | — | cohortMD1 | 0.960 |
| 6 | MNG597 | — | — | 0.960 |
| 7 | SRR1366141 | GTEX | — | 0.955 |
| 8 | MNG1259 | — | — | 0.952 |
| 9 | MNG1133 | — | — | 0.950 |
| 10 | MNG1044 | — | — | 0.948 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.475 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.385 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.367 | Inavolisib | — uncovered |
| COAGULATION | 0.145 | Binimetinib | — uncovered |
| MYOGENESIS | 0.115 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.098 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.090 | Inavolisib | — uncovered |
| BILE_ACID_METABOLISM | 0.009 | Inavolisib | — uncovered |