Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BSR_15_0113_A1_S103

· C

cf95a951-acfe-51a8-818f-64e132307f6b

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
C
subtype
C

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

8 twins match this tumor's tissue · 2 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1TCGA-AO-A0JE-01A-11R-A056-07
breast-umap@18
C0.882
220100100.Her2HRpos
breast-umap@18
D0.865
3SRR8518191
breast-umap@18
D0.861
4s0122306
melanoma-umap@29
0.854
5TCGA-AO-A12D-01A-11R-A115-07
breast-umap@18
C0.851
620060029.TNBC
breast-umap@18
D0.849
7a552cdf6.4113.4da4.8e5d.2f3d5555c74e
lung-landscapes@6
cohortMD20.848
8BS_Z7Y2466H
brain-umap@2
pilocytic astrocytoma0.846
9BS_X91K8KMG
brain-umap@2
pilocytic astrocytoma0.845
10f40a9044-a36a-4091-8783-0815792c56f7
colon-landscapes@1
0.844

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 36 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
EPITHELIAL_MESENCHYMAL_TRANSITION0.420Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.420Idelalisib— uncovered
HEDGEHOG_SIGNALING0.400Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.380Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.370Idelalisib— uncovered
TNFA_SIGNALING_VIA_NFKB0.360Inavolisib— uncovered
ALLOGRAFT_REJECTION0.350Idelalisib— uncovered
COAGULATION0.350Binimetinib— uncovered
COMPLEMENT0.350Inavolisib— uncovered
INTERFERON_ALPHA_RESPONSE0.260Inavolisib— uncovered
IL2_STAT5_SIGNALING0.250Idelalisib— uncovered
ANDROGEN_RESPONSE0.230Inavolisib— uncovered
CHOLESTEROL_HOMEOSTASIS0.230Remibrutinib— uncovered
APICAL_SURFACE0.210Temsirolimus— uncovered
TGF_BETA_SIGNALING0.210Inavolisib— uncovered
ANGIOGENESIS0.190Remibrutinib— uncovered
PI3K_AKT_MTOR_SIGNALING0.190Inavolisib— uncovered
APICAL_JUNCTION0.180Inavolisib— uncovered
KRAS_SIGNALING_UP0.160Inavolisib— uncovered
PROTEIN_SECRETION0.160Remibrutinib— uncovered