f40a9044-a36a-4091-8783-0815792c56f7
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- age_years
- 60
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- IL6_JAK_STAT3_SIGNALING+0.480
- ANGIOGENESIS+0.450
- INFLAMMATORY_RESPONSE+0.440
- INTERFERON_GAMMA_RESPONSE+0.440
- COMPLEMENT+0.430
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.430
- KRAS_SIGNALING_UP+0.410
- PROTEIN_SECRETION+0.410
- ALLOGRAFT_REJECTION+0.400
- INTERFERON_ALPHA_RESPONSE+0.380
Top 10 suppressed
- WNT_BETA_CATENIN_SIGNALING-0.330
- G2M_CHECKPOINT-0.280
- MYC_TARGETS_V2-0.280
- OXIDATIVE_PHOSPHORYLATION-0.260
- E2F_TARGETS-0.250
- NOTCH_SIGNALING-0.180
- DNA_REPAIR-0.170
- MITOTIC_SPINDLE-0.170
- PANCREAS_BETA_CELLS-0.130
- PEROXISOME-0.090
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | a552cdf6.4113.4da4.8e5d.2f3d5555c74e | — | cohortMD2 | 0.901 |
| 2 | BS_QH82PBMB | pilocytic astrocytoma | — | 0.866 |
| 3 | BS_W3R88RFP | pilocytic astrocytoma | — | 0.863 |
| 4 | 110682 | EPN | Supratentorial EPN | 0.859 |
| 5 | MBCProject_5809_T1_RNA | — | C | 0.852 |
| 6 | SRR6013590 | — | cohortA1 | 0.845 |
| 7 | BS_52426AMF | low-grade glioma | — | 0.844 |
| 8 | BSR_15_0113_A1_S103 | — | C | 0.844 |
| 9 | MBCProject_0734_T1K_RNA | — | C | 0.843 |
| 10 | SRR8526722 | — | cohortMD2 | 0.840 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 33 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| IL6_JAK_STAT3_SIGNALING | 0.480 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.450 | Remibrutinib | — uncovered |
| INFLAMMATORY_RESPONSE | 0.440 | Idelalisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.440 | Idelalisib | — uncovered |
| COMPLEMENT | 0.430 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.430 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.410 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.410 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.400 | Idelalisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.380 | Inavolisib | — uncovered |
| TNFA_SIGNALING_VIA_NFKB | 0.380 | Inavolisib | — uncovered |
| COAGULATION | 0.340 | Binimetinib | — uncovered |
| HYPOXIA | 0.310 | Idelalisib | — uncovered |
| MTORC1_SIGNALING | 0.220 | Inavolisib | — uncovered |
| APOPTOSIS | 0.200 | Idelalisib | — uncovered |
| APICAL_JUNCTION | 0.190 | Inavolisib | — uncovered |
| IL2_STAT5_SIGNALING | 0.190 | Idelalisib | — uncovered |
| UNFOLDED_PROTEIN_RESPONSE | 0.170 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.150 | Inavolisib | — uncovered |
| UV_RESPONSE_UP | 0.140 | Idelalisib | — uncovered |