TCGA-D6-A4ZB-01A-11R-A24Z-07
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
- sex
- male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- XENOBIOTIC_METABOLISM+0.190
- HYPOXIA+0.160
- BILE_ACID_METABOLISM+0.130
- COAGULATION+0.130
- P53_PATHWAY+0.130
- KRAS_SIGNALING_DN+0.090
- CHOLESTEROL_HOMEOSTASIS+0.080
- PEROXISOME+0.070
- PANCREAS_BETA_CELLS+0.030
- WNT_BETA_CATENIN_SIGNALING+0.000
Top 10 suppressed
- E2F_TARGETS-0.530
- INTERFERON_ALPHA_RESPONSE-0.530
- G2M_CHECKPOINT-0.500
- INTERFERON_GAMMA_RESPONSE-0.490
- MITOTIC_SPINDLE-0.440
- PROTEIN_SECRETION-0.420
- ALLOGRAFT_REJECTION-0.370
- ANDROGEN_RESPONSE-0.360
- IL6_JAK_STAT3_SIGNALING-0.340
- MYC_TARGETS_V2-0.340
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_3946_T4_RNA | — | A | 0.856 |
| 2 | TCGA-E2-A1B4-01A-11R-A12P-07 | — | B | 0.840 |
| 3 | TCGA-W8-A86G-01A-21R-A36F-07 | — | A | 0.839 |
| 4 | SRR1313097 | — | A | 0.834 |
| 5 | TCGA-UY-A78O-01A-12R-A33J-07 | — | — | 0.831 |
| 6 | 3d1f44d8-6084-47cb-b57b-099f2cd1fa0e | — | — | 0.829 |
| 7 | R71 | — | — | 0.826 |
| 8 | TCGA-YF-AA3L-01A-11R-A38B-07 | — | — | 0.823 |
| 9 | SRR1316535 | GTEX | — | 0.822 |
| 10 | SRR8613724 | — | F | 0.821 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| XENOBIOTIC_METABOLISM | 0.190 | Inavolisib | — uncovered |
| HYPOXIA | 0.160 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.130 | Inavolisib | — uncovered |
| COAGULATION | 0.130 | Binimetinib | — uncovered |
| P53_PATHWAY | 0.130 | Idelalisib | — uncovered |
| KRAS_SIGNALING_DN | 0.090 | Remibrutinib | — uncovered |
| CHOLESTEROL_HOMEOSTASIS | 0.080 | Remibrutinib | — uncovered |
| PEROXISOME | 0.070 | Idelalisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.030 | Cobimetinib | — uncovered |