Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

SRR934922

cfd096d3-eebe-50b8-90c4-4ad84a28f0b3

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
17.509855453350852
age_years
30
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • PROTEIN_SECRETION+0.574
  • INTERFERON_ALPHA_RESPONSE+0.481
  • MYC_TARGETS_V1+0.466
  • E2F_TARGETS+0.462
  • G2M_CHECKPOINT+0.433
  • TGF_BETA_SIGNALING+0.411
  • MITOTIC_SPINDLE+0.408
  • INTERFERON_GAMMA_RESPONSE+0.396
  • ANDROGEN_RESPONSE+0.343
  • OXIDATIVE_PHOSPHORYLATION+0.338

Top 10 suppressed

  • KRAS_SIGNALING_DN-0.485
  • SPERMATOGENESIS-0.300
  • MYOGENESIS-0.294
  • PANCREAS_BETA_CELLS-0.203
  • HEDGEHOG_SIGNALING-0.129
  • ESTROGEN_RESPONSE_EARLY-0.128
  • UV_RESPONSE_UP-0.126
  • APICAL_SURFACE-0.121
  • XENOBIOTIC_METABOLISM-0.121
  • ESTROGEN_RESPONSE_LATE-0.114

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
131A652B1-3BEB-4D78-BCA0-4C153EBC41E8
brain-umap@2
0.910
2SRR934878
brain-umap@2
0.909
3E6AA40DA-9AB7-478B-B46B-827F9AFE52D1
brain-umap@2
0.907
4SRR934925
brain-umap@2
0.906
52F382D6A-B26F-450A-A156-9407D14538CD
brain-umap@2
0.899
67604968C-689A-458D-96BA-33B163B238F8
brain-umap@2
0.895
70F8BE394-BA6A-401C-87D0-9B3CF50FB0C8
brain-umap@2
0.893
8SRR934895
brain-umap@2
0.892
9SRR934942
brain-umap@2
0.891
10AB522ACF-5D84-41B0-9671-CE2511EBD94F
brain-umap@2
0.890

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 37 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.574Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.481Inavolisib— uncovered
MYC_TARGETS_V10.466Inavolisib— uncovered
E2F_TARGETS0.462Inavolisib— uncovered
G2M_CHECKPOINT0.433Inavolisib— uncovered
TGF_BETA_SIGNALING0.411Inavolisib— uncovered
MITOTIC_SPINDLE0.408Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.396Idelalisib— uncovered
ANDROGEN_RESPONSE0.343Inavolisib— uncovered
OXIDATIVE_PHOSPHORYLATION0.338Remibrutinib— uncovered
UNFOLDED_PROTEIN_RESPONSE0.338Idelalisib— uncovered
MTORC1_SIGNALING0.317Inavolisib— uncovered
NOTCH_SIGNALING0.315Inavolisib— uncovered
DNA_REPAIR0.304Idelalisib— uncovered
UV_RESPONSE_DN0.297Inavolisib— uncovered
ADIPOGENESIS0.259Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.241Inavolisib— uncovered
MYC_TARGETS_V20.229Idelalisib— uncovered
PI3K_AKT_MTOR_SIGNALING0.222Inavolisib— uncovered
ALLOGRAFT_REJECTION0.190Idelalisib— uncovered