Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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SRR1418127

GTEX

d236c538-d4c7-507d-b95f-2da4b70b94e4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
GTEX
cancer_type_detailed
subtype
cancer_type
GTEX
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

7 twins match this tumor's tissue · 3 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1SRR1375976
brain-umap@2
GTEX0.972
2SRR1435484
brain-umap@2
GTEX0.965
3BS_C7N3J4NW
brain-umap@2
high-grade glioma0.962
4SRR1314958
brain-umap@2
GTEX0.962
5SRR614900
brain-umap@2
GTEX0.959
6BS_3T6X4BPC
brain-umap@2
DNET0.958
7BS_KPT2WPHW
brain-umap@2
Ganglioglioma0.954
8SRR1407134
brain-umap@2
GTEX0.954
9SRR1477080
brain-umap@2
GTEX0.953
10SRR1388378
brain-umap@2
GTEX0.953

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 16 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
KRAS_SIGNALING_DN0.494Remibrutinib— uncovered
PANCREAS_BETA_CELLS0.434Cobimetinib— uncovered
APICAL_SURFACE0.296Temsirolimus— uncovered
SPERMATOGENESIS0.255Inavolisib— uncovered
ANGIOGENESIS0.217Remibrutinib— uncovered
HEDGEHOG_SIGNALING0.206Inavolisib— uncovered
MYOGENESIS0.187Inavolisib— uncovered
UV_RESPONSE_DN0.180Inavolisib— uncovered
ESTROGEN_RESPONSE_EARLY0.164Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.160Idelalisib— uncovered
KRAS_SIGNALING_UP0.122Inavolisib— uncovered
BILE_ACID_METABOLISM0.115Inavolisib— uncovered
APICAL_JUNCTION0.105Inavolisib— uncovered
EPITHELIAL_MESENCHYMAL_TRANSITION0.039Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.038Inavolisib— uncovered
COAGULATION0.007Binimetinib— uncovered