Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

TCGA-2F-A9KQ-01A-11R-A38B-07

d5dfb6b2-ee2a-5f6b-ab07-a1cf6e4f46b1

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
cancer_type_detailed
subtype
overall_survival_months
94.80946124
os_event
false
sex
Male

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

  • ANGIOGENESIS+0.370
  • BILE_ACID_METABOLISM+0.310
  • PANCREAS_BETA_CELLS+0.300
  • P53_PATHWAY+0.260
  • TGF_BETA_SIGNALING+0.220
  • HYPOXIA+0.210
  • ADIPOGENESIS+0.190
  • PROTEIN_SECRETION+0.190
  • COAGULATION+0.160
  • XENOBIOTIC_METABOLISM+0.160

Top 10 suppressed

  • INTERFERON_ALPHA_RESPONSE-0.580
  • INTERFERON_GAMMA_RESPONSE-0.530
  • ALLOGRAFT_REJECTION-0.500
  • MYC_TARGETS_V2-0.450
  • MYC_TARGETS_V1-0.360
  • TNFA_SIGNALING_VIA_NFKB-0.340
  • E2F_TARGETS-0.330
  • INFLAMMATORY_RESPONSE-0.330
  • IL6_JAK_STAT3_SIGNALING-0.320
  • G2M_CHECKPOINT-0.300

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1aMVAC.P_003_TURBT_S220
bladder-landscape@3
0.819
2SRR8518184
breast-umap@18
F0.812
3sclcCHTN02019_S70.txt
lung-landscapes@6
cohortSC0.810
4SRR25617843
breast-umap@18
B0.803
5SRR8613754
breast-umap@18
F0.784
635c6ff25-753c-4ebe-bbe7-2e7105d052e8
melanoma-umap@29
0.782
7C3L-02834
lung-landscapes@6
cohortA10.779
8SRR8518290
breast-umap@18
F0.772
9TCGA-B6-A1KI-01A-11R-A14M-07
breast-umap@18
B0.770
10SRR29022834
breast-umap@18
A0.766

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 23 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
ANGIOGENESIS0.370Remibrutinib— uncovered
BILE_ACID_METABOLISM0.310Inavolisib— uncovered
PANCREAS_BETA_CELLS0.300Cobimetinib— uncovered
P53_PATHWAY0.260Idelalisib— uncovered
TGF_BETA_SIGNALING0.220Inavolisib— uncovered
HYPOXIA0.210Idelalisib— uncovered
ADIPOGENESIS0.190Inavolisib— uncovered
PROTEIN_SECRETION0.190Remibrutinib— uncovered
COAGULATION0.160Binimetinib— uncovered
XENOBIOTIC_METABOLISM0.160Inavolisib— uncovered
GLYCOLYSIS0.150Inavolisib— uncovered
HEDGEHOG_SIGNALING0.150Inavolisib— uncovered
ESTROGEN_RESPONSE_LATE0.130Idelalisib— uncovered
PEROXISOME0.120Idelalisib— uncovered
HEME_METABOLISM0.110Temsirolimus— uncovered
KRAS_SIGNALING_DN0.100Remibrutinib— uncovered
ESTROGEN_RESPONSE_EARLY0.090Inavolisib— uncovered
ANDROGEN_RESPONSE0.060Inavolisib— uncovered
MYOGENESIS0.060Inavolisib— uncovered
UV_RESPONSE_UP0.050Idelalisib— uncovered