SRR25617900
— · A
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- A
- subtype
- A
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.290
- UV_RESPONSE_DN+0.290
- INTERFERON_GAMMA_RESPONSE+0.180
- TGF_BETA_SIGNALING+0.080
- INTERFERON_ALPHA_RESPONSE+0.070
- KRAS_SIGNALING_UP+0.070
- ALLOGRAFT_REJECTION+0.060
- ANDROGEN_RESPONSE+0.060
- COMPLEMENT+0.050
- WNT_BETA_CATENIN_SIGNALING+0.050
Top 10 suppressed
- MYC_TARGETS_V2-0.470
- E2F_TARGETS-0.400
- G2M_CHECKPOINT-0.400
- MYC_TARGETS_V1-0.390
- ESTROGEN_RESPONSE_LATE-0.380
- ANGIOGENESIS-0.350
- GLYCOLYSIS-0.350
- ESTROGEN_RESPONSE_EARLY-0.330
- MTORC1_SIGNALING-0.330
- APICAL_SURFACE-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_5856_T0B_RNA | — | A | 0.858 |
| 2 | TCGA-E2-A15I-01A-21R-A137-07 | — | B | 0.852 |
| 3 | TCGA-44-5645-01A-01R-A278-07 | — | cohortMD2 | 0.849 |
| 4 | 20030061.LumA | — | A | 0.844 |
| 5 | TCGA-44-5645-01A-01R-1628-07 | — | cohortA1 | 0.831 |
| 6 | MNG881 | — | — | 0.816 |
| 7 | TCGA-AO-A0JG-01A-31R-A084-07 | — | A | 0.804 |
| 8 | TCGA-55-7573-01A-11R-2039-07 | — | cohortA1 | 0.802 |
| 9 | TCGA-A7-A26J-01B-02R-A277-07 | — | D | 0.795 |
| 10 | C3N-03054 | — | cohortA1 | 0.786 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 11 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.290 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.290 | Inavolisib | — uncovered |
| INTERFERON_GAMMA_RESPONSE | 0.180 | Idelalisib | — uncovered |
| TGF_BETA_SIGNALING | 0.080 | Inavolisib | — uncovered |
| INTERFERON_ALPHA_RESPONSE | 0.070 | Inavolisib | — uncovered |
| KRAS_SIGNALING_UP | 0.070 | Inavolisib | — uncovered |
| ALLOGRAFT_REJECTION | 0.060 | Idelalisib | — uncovered |
| ANDROGEN_RESPONSE | 0.060 | Inavolisib | — uncovered |
| COMPLEMENT | 0.050 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.050 | Inavolisib | — uncovered |
| COAGULATION | 0.020 | Binimetinib | — uncovered |