2bd0477f-40af-4969-9291-c05ab3d55268
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PROTEIN_SECRETION+0.400
- ANGIOGENESIS+0.100
- BILE_ACID_METABOLISM+0.100
- ESTROGEN_RESPONSE_EARLY+0.100
- HEME_METABOLISM+0.100
- MITOTIC_SPINDLE+0.100
- P53_PATHWAY+0.100
- PEROXISOME+0.100
- ANDROGEN_RESPONSE+0.000
- APICAL_JUNCTION+0.000
Top 10 suppressed
- ALLOGRAFT_REJECTION-0.500
- INTERFERON_GAMMA_RESPONSE-0.500
- MYC_TARGETS_V2-0.500
- E2F_TARGETS-0.400
- IL6_JAK_STAT3_SIGNALING-0.400
- INFLAMMATORY_RESPONSE-0.400
- INTERFERON_ALPHA_RESPONSE-0.400
- COMPLEMENT-0.300
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.300
- G2M_CHECKPOINT-0.300
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12475149 | — | — | 0.816 |
| 2 | TCGA-D8-A27P-01A-11R-A16F-07 | — | B | 0.807 |
| 3 | SRR1516046 | — | — | 0.803 |
| 4 | TCGA-D8-A1XC-01A-11R-A14D-07 | — | B | 0.803 |
| 5 | MNG620 | — | — | 0.794 |
| 6 | 8c7c9bb7-76e0-480c-a0de-bbf48fa398f4 | — | — | 0.793 |
| 7 | SRR1516060 | — | — | 0.791 |
| 8 | 20030017.LumA | — | B | 0.789 |
| 9 | MDT-AP-0180 | Med | Medulloblastoma | 0.788 |
| 10 | TCGA-A7-A13G-01A-11R-A13Q-07 | — | D | 0.788 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.400 | Remibrutinib | — uncovered |
| ANGIOGENESIS | 0.100 | Remibrutinib | — uncovered |
| BILE_ACID_METABOLISM | 0.100 | Inavolisib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.100 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.100 | Temsirolimus | — uncovered |
| MITOTIC_SPINDLE | 0.100 | Inavolisib | — uncovered |
| P53_PATHWAY | 0.100 | Idelalisib | — uncovered |
| PEROXISOME | 0.100 | Idelalisib | — uncovered |