MDT-AP-0734
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- overall_survival_months
- 120
- os_event
- false
- age_years
- 12
- sex
- M
- new_clusters
- C6
- umap1_2d
- 3.92423713
- umap2_2d
- 6.650686401
- umap1_3d
- 3.072664123
- umap2_3d
- -0.634126588
- umap3_3d
- -4.561271563
- dataset
- Med-Taylor
GSVA pathway preview (0 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0153 | Med | Medulloblastoma | 0.946 |
| 2 | MDT-AP-3267 | Med | Medulloblastoma | 0.917 |
| 3 | MDT-AP-0830 | Med | Medulloblastoma | 0.916 |
| 4 | MDT-AP-0393 | Med | Medulloblastoma | 0.902 |
| 5 | MDT-AP-0838 | Med | Medulloblastoma | 0.896 |
| 6 | MDT-AP-0808 | Med | Medulloblastoma | 0.888 |
| 7 | MDT-AP-0376 | Med | Medulloblastoma | 0.888 |
| 8 | MDT-AP-0364 | Med | Medulloblastoma | 0.879 |
| 9 | BS_A87NPZAP | Med | Medulloblastoma | 0.867 |
| 10 | MDT-AP-0373 | Med | Medulloblastoma | 0.864 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PROTEIN_SECRETION | 0.150 | Remibrutinib | — uncovered |
| HEME_METABOLISM | 0.110 | Temsirolimus | — uncovered |
| NOTCH_SIGNALING | 0.100 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.070 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.030 | Temsirolimus | — uncovered |