MDT-AP-3267
Med · Medulloblastoma
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- Med
- cancer_type_detailed
- —
- subtype
- Medulloblastoma
- cancer_type
- Med
- subtype
- Medulloblastoma
- age_years
- 6.5
- sex
- M
- new_clusters
- C5
- umap1_2d
- 3.726859344
- umap2_2d
- 5.135219578
- umap1_3d
- 2.743412889
- umap2_3d
- -2.112791814
- umap3_3d
- -3.626623943
- dataset
- Med-Taylor
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- HEDGEHOG_SIGNALING+0.230
- HEME_METABOLISM+0.090
- PROTEIN_SECRETION+0.080
- SPERMATOGENESIS+0.060
- WNT_BETA_CATENIN_SIGNALING+0.050
- BILE_ACID_METABOLISM-0.010
- UV_RESPONSE_DN-0.010
- ESTROGEN_RESPONSE_EARLY-0.030
- KRAS_SIGNALING_DN-0.040
- PI3K_AKT_MTOR_SIGNALING-0.080
Top 10 suppressed
- MYC_TARGETS_V1-0.510
- E2F_TARGETS-0.490
- OXIDATIVE_PHOSPHORYLATION-0.470
- DNA_REPAIR-0.430
- MYC_TARGETS_V2-0.430
- G2M_CHECKPOINT-0.420
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.400
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.370
- UV_RESPONSE_UP-0.350
- MTORC1_SIGNALING-0.340
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | TCGA-A7-A13G-01B-04R-A22O-07 | — | D | 0.932 |
| 2 | MDT-AP-0734 | Med | Medulloblastoma | 0.917 |
| 3 | MDT-AP-0153 | Med | Medulloblastoma | 0.915 |
| 4 | C3L-04759 | — | cohortA1 | 0.908 |
| 5 | ERR2598056 | fetal | fetal | 0.903 |
| 6 | MDT-AP-0376 | Med | Medulloblastoma | 0.887 |
| 7 | SRR23303736 | — | — | 0.887 |
| 8 | TCGA-A7-A0DC-01B-04R-A22O-07 | — | D | 0.886 |
| 9 | BS_0Y66ZBWE | low-grade glioma | — | 0.884 |
| 10 | C3N-00293 | — | cohortA1 | 0.883 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| HEDGEHOG_SIGNALING | 0.230 | Inavolisib | — uncovered |
| HEME_METABOLISM | 0.090 | Temsirolimus | — uncovered |
| PROTEIN_SECRETION | 0.080 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.060 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.050 | Inavolisib | — uncovered |