20a06f04-b457-408f-8c3c-f0032badf064
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Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
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- cancer_type_detailed
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- subtype
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GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.400
- PANCREAS_BETA_CELLS+0.400
- ANGIOGENESIS+0.200
- ALLOGRAFT_REJECTION+0.100
- SPERMATOGENESIS+0.100
- KRAS_SIGNALING_UP+0.000
- MYOGENESIS+0.000
- UV_RESPONSE_UP+0.000
- BILE_ACID_METABOLISM-0.100
- COAGULATION-0.100
Top 10 suppressed
- MITOTIC_SPINDLE-0.500
- MTORC1_SIGNALING-0.500
- PI3K_AKT_MTOR_SIGNALING-0.500
- PROTEIN_SECRETION-0.500
- TGF_BETA_SIGNALING-0.500
- UNFOLDED_PROTEIN_RESPONSE-0.500
- ANDROGEN_RESPONSE-0.400
- DNA_REPAIR-0.400
- G2M_CHECKPOINT-0.400
- UV_RESPONSE_DN-0.400
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MDT-AP-0706 | Med | Medulloblastoma | 0.914 |
| 2 | MNG923 | — | — | 0.910 |
| 3 | MNG506 | — | — | 0.909 |
| 4 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.909 |
| 5 | MNG597 | — | — | 0.907 |
| 6 | TCGA-CF-A3MI-01A-11R-A20F-07 | — | — | 0.904 |
| 7 | TCGA-DK-A1A7-01A-11R-A13Y-07 | — | — | 0.902 |
| 8 | MNG90 | — | — | 0.891 |
| 9 | MNG599 | — | — | 0.891 |
| 10 | msclc569389_S35.txt | — | cohortMD1 | 0.891 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 5 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.400 | Remibrutinib | — uncovered |
| PANCREAS_BETA_CELLS | 0.400 | Cobimetinib | — uncovered |
| ANGIOGENESIS | 0.200 | Remibrutinib | — uncovered |
| ALLOGRAFT_REJECTION | 0.100 | Idelalisib | — uncovered |
| SPERMATOGENESIS | 0.100 | Inavolisib | — uncovered |