MNG90
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.412
- KRAS_SIGNALING_DN+0.310
- SPERMATOGENESIS+0.286
- ANGIOGENESIS+0.098
- COAGULATION+0.016
- KRAS_SIGNALING_UP+0.007
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.016
- BILE_ACID_METABOLISM-0.084
- ESTROGEN_RESPONSE_LATE-0.087
- ALLOGRAFT_REJECTION-0.104
Top 10 suppressed
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.597
- DNA_REPAIR-0.527
- PROTEIN_SECRETION-0.504
- OXIDATIVE_PHOSPHORYLATION-0.491
- MYC_TARGETS_V1-0.485
- MYC_TARGETS_V2-0.484
- UNFOLDED_PROTEIN_RESPONSE-0.472
- PI3K_AKT_MTOR_SIGNALING-0.468
- ADIPOGENESIS-0.460
- INTERFERON_ALPHA_RESPONSE-0.453
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
8 twins match this tumor's tissue · 2 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | msclc569389_S35.txt | — | cohortMD1 | 0.975 |
| 2 | MNG1131 | — | — | 0.973 |
| 3 | MNG598 | — | — | 0.973 |
| 4 | MNG597 | — | — | 0.970 |
| 5 | MNG555 | — | — | 0.967 |
| 6 | SRR1366579 | GTEX | — | 0.966 |
| 7 | 08e3d239-3d8a-4eee-9e08-ac2bcb3f2619 | — | — | 0.966 |
| 8 | TCGA-CF-A3MF-01A-12R-A21D-07 | — | — | 0.960 |
| 9 | MDT-AP-0706 | Med | Medulloblastoma | 0.958 |
| 10 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.957 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.412 | Cobimetinib | — uncovered |
| KRAS_SIGNALING_DN | 0.310 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.286 | Inavolisib | — uncovered |
| ANGIOGENESIS | 0.098 | Remibrutinib | — uncovered |
| COAGULATION | 0.016 | Binimetinib | — uncovered |
| KRAS_SIGNALING_UP | 0.007 | Inavolisib | — uncovered |