SRR13311169
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYOGENESIS+0.400
- KRAS_SIGNALING_DN+0.330
- UV_RESPONSE_DN+0.290
- EPITHELIAL_MESENCHYMAL_TRANSITION+0.120
- HEDGEHOG_SIGNALING+0.090
- APICAL_JUNCTION+0.060
- APICAL_SURFACE+0.000
- SPERMATOGENESIS+0.000
- COAGULATION-0.040
- PANCREAS_BETA_CELLS-0.070
Top 10 suppressed
- MYC_TARGETS_V1-0.600
- OXIDATIVE_PHOSPHORYLATION-0.520
- E2F_TARGETS-0.510
- PROTEIN_SECRETION-0.470
- UNFOLDED_PROTEIN_RESPONSE-0.440
- MTORC1_SIGNALING-0.430
- MYC_TARGETS_V2-0.420
- G2M_CHECKPOINT-0.410
- ANDROGEN_RESPONSE-0.400
- DNA_REPAIR-0.370
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
1 twin match this tumor's tissue · 9 come from a different tissue of origin ← cross-tissue dominant
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1315269 | GTEX | — | 0.929 |
| 2 | SRR1466641 | GTEX | — | 0.920 |
| 3 | 4f0b1ac0-c503-4852-9a44-cb4231f4b17b | — | — | 0.917 |
| 4 | SRR1466850 | GTEX | — | 0.916 |
| 5 | SRR1392637 | GTEX | — | 0.915 |
| 6 | SRR1432343 | GTEX | — | 0.911 |
| 7 | SRR1335254 | GTEX | — | 0.909 |
| 8 | SRR1402454 | GTEX | — | 0.906 |
| 9 | SRR1362417 | GTEX | — | 0.906 |
| 10 | SRR1313951 | GTEX | — | 0.905 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 6 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYOGENESIS | 0.400 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.330 | Remibrutinib | — uncovered |
| UV_RESPONSE_DN | 0.290 | Inavolisib | — uncovered |
| EPITHELIAL_MESENCHYMAL_TRANSITION | 0.120 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.090 | Inavolisib | — uncovered |
| APICAL_JUNCTION | 0.060 | Inavolisib | — uncovered |