SRR8518374
— · E
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- E
- subtype
- E
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- MYC_TARGETS_V2+0.360
- MYC_TARGETS_V1+0.240
- NOTCH_SIGNALING+0.210
- WNT_BETA_CATENIN_SIGNALING+0.140
- PROTEIN_SECRETION+0.100
- ANGIOGENESIS+0.090
- MYOGENESIS+0.080
- HEDGEHOG_SIGNALING+0.040
- OXIDATIVE_PHOSPHORYLATION+0.040
- ESTROGEN_RESPONSE_EARLY+0.030
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.600
- INTERFERON_GAMMA_RESPONSE-0.550
- IL6_JAK_STAT3_SIGNALING-0.500
- ALLOGRAFT_REJECTION-0.400
- PI3K_AKT_MTOR_SIGNALING-0.390
- IL2_STAT5_SIGNALING-0.370
- COMPLEMENT-0.350
- INFLAMMATORY_RESPONSE-0.350
- TNFA_SIGNALING_VIA_NFKB-0.330
- MTORC1_SIGNALING-0.310
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | R274 | — | — | 0.869 |
| 2 | SRR8613748 | — | D | 0.847 |
| 3 | SRR8518202 | — | A | 0.838 |
| 4 | 4e24bc58-d246-4c96-952a-a18f95d142b2 | — | — | 0.831 |
| 5 | MBCProject_0297_T1_RNA | — | A | 0.816 |
| 6 | SRR5088850 | — | — | 0.813 |
| 7 | 4ce20929-7d04-4c4b-9e3c-de22d237f254 | — | — | 0.812 |
| 8 | SRR8613756 | — | E | 0.811 |
| 9 | ERR2208946 | — | — | 0.807 |
| 10 | ERR2208948 | — | — | 0.804 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 10 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| MYC_TARGETS_V2 | 0.360 | Idelalisib | — uncovered |
| MYC_TARGETS_V1 | 0.240 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.210 | Inavolisib | — uncovered |
| WNT_BETA_CATENIN_SIGNALING | 0.140 | Inavolisib | — uncovered |
| PROTEIN_SECRETION | 0.100 | Remibrutinib | — uncovered |
| ANGIOGENESIS | 0.090 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.080 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.040 | Inavolisib | — uncovered |
| OXIDATIVE_PHOSPHORYLATION | 0.040 | Remibrutinib | — uncovered |
| ESTROGEN_RESPONSE_EARLY | 0.030 | Inavolisib | — uncovered |