SRR8613748
— · D
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- D
- subtype
- D
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- WNT_BETA_CATENIN_SIGNALING+0.360
- NOTCH_SIGNALING+0.220
- MYC_TARGETS_V2+0.200
- HEDGEHOG_SIGNALING+0.080
- SPERMATOGENESIS+0.080
- MITOTIC_SPINDLE+0.050
- KRAS_SIGNALING_DN+0.020
- MYC_TARGETS_V1+0.010
- MYOGENESIS+0.010
- APICAL_JUNCTION-0.040
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.670
- INTERFERON_GAMMA_RESPONSE-0.560
- TNFA_SIGNALING_VIA_NFKB-0.410
- MTORC1_SIGNALING-0.390
- INFLAMMATORY_RESPONSE-0.380
- ALLOGRAFT_REJECTION-0.370
- TGF_BETA_SIGNALING-0.350
- ANDROGEN_RESPONSE-0.340
- IL2_STAT5_SIGNALING-0.340
- IL6_JAK_STAT3_SIGNALING-0.340
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
9 twins match this tumor's tissue · 1 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | MBCProject_0719_T1_RNA | — | A | 0.896 |
| 2 | s0102877 | — | — | 0.892 |
| 3 | TCGA-90-A4ED-01A-31R-A24Z-07 | — | cohortMD1 | 0.883 |
| 4 | SRR8518450 | — | A | 0.881 |
| 5 | TCGA-D6-6827-01A-11R-1915-07 | — | — | 0.868 |
| 6 | GSM5359422 | — | — | 0.865 |
| 7 | SRR1313141 | — | E | 0.863 |
| 8 | MDT-AP-0396 | Med | Medulloblastoma | 0.859 |
| 9 | ea635e80-1225-4f52-a6cf-8f4c20201240 | — | — | 0.859 |
| 10 | SRR650166 | — | — | 0.856 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 9 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| WNT_BETA_CATENIN_SIGNALING | 0.360 | Inavolisib | — uncovered |
| NOTCH_SIGNALING | 0.220 | Inavolisib | — uncovered |
| MYC_TARGETS_V2 | 0.200 | Idelalisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.080 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.080 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.050 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.020 | Remibrutinib | — uncovered |
| MYC_TARGETS_V1 | 0.010 | Inavolisib | — uncovered |
| MYOGENESIS | 0.010 | Inavolisib | — uncovered |