X299bbf8b.babb.4be2.a190.5411dc005aae

— · cohortA1

ec942ced-8492-572f-b4e3-936a2d4b15f4

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: cohortA1
subtype: cohortA1
age_years: 64

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

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Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

10 twins match this tumor's tissue · 0 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	SRR11296886 colon-landscapes@1	—	—	0.914
2	TCGA-56-A4BX-01A-11R-A24H-07 lung-landscapes@6	—	cohortSQ2	0.911
3	TCGA-AN-A0AR-01A-11R-A00Z-07 breast-umap@18	—	E	0.896
4	SRR8518365 breast-umap@18	—	E	0.895
5	SRR6013540 lung-landscapes@6	—	cohortSQ2	0.894
6	MNG488 mng-umap@100	—	—	0.894
7	dd75267f-824e-4ddc-9056-cdf0f500d39b melanoma-umap@29	—	—	0.893
8	ERR2208946 melanoma-umap@29	—	—	0.893
9	SRR2932822 head-neck@1	—	—	0.889
10	20040095.TNBC breast-umap@18	—	E	0.888

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 15 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
MYC_TARGETS_V2	0.440	Idelalisib	— uncovered
E2F_TARGETS	0.320	Inavolisib	— uncovered
G2M_CHECKPOINT	0.280	Inavolisib	— uncovered
MYC_TARGETS_V1	0.170	Inavolisib	— uncovered
KRAS_SIGNALING_DN	0.120	Remibrutinib	— uncovered
MITOTIC_SPINDLE	0.110	Inavolisib	— uncovered
DNA_REPAIR	0.100	Idelalisib	— uncovered
APICAL_SURFACE	0.080	Temsirolimus	— uncovered
SPERMATOGENESIS	0.050	Inavolisib	— uncovered
ADIPOGENESIS	0.040	Inavolisib	— uncovered
CHOLESTEROL_HOMEOSTASIS	0.020	Remibrutinib	— uncovered
ESTROGEN_RESPONSE_EARLY	0.020	Inavolisib	— uncovered
MYOGENESIS	0.020	Inavolisib	— uncovered
APICAL_JUNCTION	0.010	Inavolisib	— uncovered
WNT_BETA_CATENIN_SIGNALING	0.010	Inavolisib	— uncovered