SRR12202427
—
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- —
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.230
- SPERMATOGENESIS+0.210
- FATTY_ACID_METABOLISM+0.190
- PANCREAS_BETA_CELLS+0.170
- PEROXISOME+0.150
- BILE_ACID_METABOLISM+0.120
- ADIPOGENESIS+0.080
- XENOBIOTIC_METABOLISM+0.080
- KRAS_SIGNALING_DN-0.030
- CHOLESTEROL_HOMEOSTASIS-0.120
Top 10 suppressed
- TNFA_SIGNALING_VIA_NFKB-0.570
- ANGIOGENESIS-0.540
- INTERFERON_ALPHA_RESPONSE-0.530
- TGF_BETA_SIGNALING-0.520
- INTERFERON_GAMMA_RESPONSE-0.490
- P53_PATHWAY-0.470
- HYPOXIA-0.440
- IL6_JAK_STAT3_SIGNALING-0.410
- NOTCH_SIGNALING-0.390
- INFLAMMATORY_RESPONSE-0.380
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
6 twins match this tumor's tissue · 4 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR12202450 | — | — | 0.929 |
| 2 | SRR934734 | — | — | 0.907 |
| 3 | SRR2700736 | — | — | 0.900 |
| 4 | SRR657348 | GTEX | — | 0.895 |
| 5 | TCGA-E9-A245-01A-22R-A16F-07 | — | B | 0.889 |
| 6 | SRR8943038 | — | — | 0.887 |
| 7 | SRR1367870 | GTEX | — | 0.887 |
| 8 | SRR1324431 | GTEX | — | 0.886 |
| 9 | TCGA-E5-A4U1-01A-11R-A31N-07 | — | — | 0.885 |
| 10 | SRR1471435 | GTEX | — | 0.885 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.230 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.210 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.190 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.170 | Cobimetinib | — uncovered |
| PEROXISOME | 0.150 | Idelalisib | — uncovered |
| BILE_ACID_METABOLISM | 0.120 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.080 | Inavolisib | — uncovered |
| XENOBIOTIC_METABOLISM | 0.080 | Inavolisib | — uncovered |