SRR657348
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Female
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- OXIDATIVE_PHOSPHORYLATION+0.354
- KRAS_SIGNALING_DN+0.209
- SPERMATOGENESIS+0.149
- FATTY_ACID_METABOLISM+0.141
- ADIPOGENESIS+0.053
- MYOGENESIS+0.044
- HEDGEHOG_SIGNALING+0.041
- PEROXISOME+0.001
- REACTIVE_OXYGEN_SPECIES_PATHWAY-0.008
- UV_RESPONSE_DN-0.011
Top 10 suppressed
- INTERFERON_ALPHA_RESPONSE-0.504
- TNFA_SIGNALING_VIA_NFKB-0.476
- CHOLESTEROL_HOMEOSTASIS-0.474
- IL6_JAK_STAT3_SIGNALING-0.455
- INTERFERON_GAMMA_RESPONSE-0.451
- ANGIOGENESIS-0.440
- INFLAMMATORY_RESPONSE-0.401
- MYC_TARGETS_V2-0.397
- EPITHELIAL_MESENCHYMAL_TRANSITION-0.384
- ALLOGRAFT_REJECTION-0.375
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1474065 | GTEX | — | 0.958 |
| 2 | SRR1335651 | GTEX | — | 0.958 |
| 3 | SRR1353157 | GTEX | — | 0.956 |
| 4 | SRR1339218 | GTEX | — | 0.955 |
| 5 | SRR1359192 | GTEX | — | 0.953 |
| 6 | SRR1322555 | GTEX | — | 0.951 |
| 7 | SRR1324431 | GTEX | — | 0.950 |
| 8 | SRR1367870 | GTEX | — | 0.948 |
| 9 | SRR1471435 | GTEX | — | 0.948 |
| 10 | SRR1359388 | GTEX | — | 0.945 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| OXIDATIVE_PHOSPHORYLATION | 0.354 | Remibrutinib | — uncovered |
| KRAS_SIGNALING_DN | 0.209 | Remibrutinib | — uncovered |
| SPERMATOGENESIS | 0.149 | Inavolisib | — uncovered |
| FATTY_ACID_METABOLISM | 0.141 | Inavolisib | — uncovered |
| ADIPOGENESIS | 0.053 | Inavolisib | — uncovered |
| MYOGENESIS | 0.044 | Inavolisib | — uncovered |
| HEDGEHOG_SIGNALING | 0.041 | Inavolisib | — uncovered |
| PEROXISOME | 0.001 | Idelalisib | — uncovered |