ERR4976615

— · D

e27d3871-3fe5-53b5-a609-e418a9fb4694

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type: —
cancer_type_detailed: —
subtype: D
subtype: D
overall_survival_months: 24

GSVA pathway preview (50 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

Top 10 elevated

KRAS_SIGNALING_DN+0.350
SPERMATOGENESIS+0.340
PANCREAS_BETA_CELLS+0.090
BILE_ACID_METABOLISM+0.070
HEDGEHOG_SIGNALING-0.020
MYOGENESIS-0.020
COAGULATION-0.080
NOTCH_SIGNALING-0.080
WNT_BETA_CATENIN_SIGNALING-0.080
PEROXISOME-0.110

Top 10 suppressed

TGF_BETA_SIGNALING-0.470
TNFA_SIGNALING_VIA_NFKB-0.440
UNFOLDED_PROTEIN_RESPONSE-0.440
MYC_TARGETS_V1-0.430
REACTIVE_OXYGEN_SPECIES_PATHWAY-0.430
IL6_JAK_STAT3_SIGNALING-0.400
OXIDATIVE_PHOSPHORYLATION-0.380
PROTEIN_SECRETION-0.370
MTORC1_SIGNALING-0.360
ADIPOGENESIS-0.350

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

6 twins match this tumor's tissue · 4 come from a different tissue of origin

#	Sample	Cancer type	Subtype	cos similarity
1	BS_4GTESTSE brain-umap@2	Ganglioglioma	—	0.955
2	SRR934787 brain-umap@2	—	—	0.953
3	ERR4976613 breast-umap@18	—	D	0.953
4	SRR26320081 bladder-landscape@3	—	—	0.951
5	SRR1797231 lung-landscapes@6	—	cohortSC	0.949
6	MDT-AP-3189 medullo-epn-umap@date-based	Med	Medulloblastoma	0.946
7	SRR602927 brain-umap@2	GTEX	—	0.945
8	SRR4195666 colon-landscapes@1	—	—	0.945
9	SRR1478032 brain-umap@2	GTEX	—	0.944
10	ERR4976608 breast-umap@18	—	D	0.944

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 4 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)	tumor score	Best drug	reversal magnitude
KRAS_SIGNALING_DN	0.350	Remibrutinib	— uncovered
SPERMATOGENESIS	0.340	Inavolisib	— uncovered
PANCREAS_BETA_CELLS	0.090	Cobimetinib	— uncovered
BILE_ACID_METABOLISM	0.070	Inavolisib	— uncovered