Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.

BS_CTR5X93B

pilocytic astrocytoma

f44d8ef5-20e8-5e13-970d-2d0c388169df

Score in workbench →

Clinical attributes

From the source cohort, normalized into canonical keys plus the project's native columns.

cancer_type
pilocytic astrocytoma
cancer_type_detailed
subtype
cancer_type
pilocytic astrocytoma
overall_survival_months
37.417871222076215
age_years
5.255
sex
Male

GSVA pathway preview (0 Hallmark scores)

MeasuredDerivedReference

Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.

No GSVA scores available for this sample.

Patient twins — nearest pathway neighbors

MeasuredDerived

10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.

9 twins match this tumor's tissue · 1 come from a different tissue of origin

#SampleCancer typeSubtypecos similarity
1BS_YVMEEBKC
brain-umap@2
pilocytic astrocytoma0.907
2BS_JMHG7GCN
brain-umap@2
pilocytic astrocytoma0.880
3BS_4HQ3T2NC
brain-umap@2
pilocytic astrocytoma0.880
4BS_2ADZNNV4
brain-umap@2
pilocytic astrocytoma0.880
5SRR17866835
colon-landscapes@1
0.879
6MDT-AP-3274
medullo-epn-umap@date-based
MedMedulloblastoma0.878
7BS_H8A9PSYA
brain-umap@2
pilocytic astrocytoma0.875
8BS_MY9D8XZ1
brain-umap@2
pilocytic astrocytoma0.871
9BS_42DY6WS7
brain-umap@2
pilocytic astrocytoma0.864
10TCGA-A7-A0CG-01A-12R-A056-07
breast-umap@18
A0.864

Per-pathway drug coverage

ModeledCalibratedDerived

For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.

0 of 30 elevated pathways have at least one drug that meaningfully reverses them.

Pathway (elevated)tumor scoreBest drugreversal magnitude
PROTEIN_SECRETION0.458Remibrutinib— uncovered
INTERFERON_ALPHA_RESPONSE0.427Inavolisib— uncovered
INTERFERON_GAMMA_RESPONSE0.386Idelalisib— uncovered
ALLOGRAFT_REJECTION0.382Idelalisib— uncovered
BILE_ACID_METABOLISM0.335Inavolisib— uncovered
ANDROGEN_RESPONSE0.326Inavolisib— uncovered
IL6_JAK_STAT3_SIGNALING0.311Inavolisib— uncovered
INFLAMMATORY_RESPONSE0.285Idelalisib— uncovered
IL2_STAT5_SIGNALING0.280Idelalisib— uncovered
APICAL_SURFACE0.268Temsirolimus— uncovered
HEME_METABOLISM0.266Temsirolimus— uncovered
ADIPOGENESIS0.259Inavolisib— uncovered
COMPLEMENT0.247Inavolisib— uncovered
UV_RESPONSE_DN0.237Inavolisib— uncovered
COAGULATION0.233Binimetinib— uncovered
FATTY_ACID_METABOLISM0.231Inavolisib— uncovered
KRAS_SIGNALING_UP0.230Inavolisib— uncovered
XENOBIOTIC_METABOLISM0.183Inavolisib— uncovered
TGF_BETA_SIGNALING0.180Inavolisib— uncovered
MYOGENESIS0.163Inavolisib— uncovered