sclc1081_S46.txt
— · cohortSC
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- —
- cancer_type_detailed
- —
- subtype
- cohortSC
- subtype
- cohortSC
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- PANCREAS_BETA_CELLS+0.360
- SPERMATOGENESIS+0.170
- KRAS_SIGNALING_DN+0.110
- HEDGEHOG_SIGNALING+0.050
- APICAL_SURFACE-0.010
- MYC_TARGETS_V2-0.020
- BILE_ACID_METABOLISM-0.030
- UV_RESPONSE_DN-0.080
- INFLAMMATORY_RESPONSE-0.130
- PEROXISOME-0.150
Top 10 suppressed
- PROTEIN_SECRETION-0.430
- TNFA_SIGNALING_VIA_NFKB-0.430
- INTERFERON_ALPHA_RESPONSE-0.390
- CHOLESTEROL_HOMEOSTASIS-0.380
- UNFOLDED_PROTEIN_RESPONSE-0.380
- MYC_TARGETS_V1-0.370
- UV_RESPONSE_UP-0.370
- APOPTOSIS-0.360
- ESTROGEN_RESPONSE_LATE-0.350
- WNT_BETA_CATENIN_SIGNALING-0.350
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | ERR4976605 | — | D | 0.953 |
| 2 | SRR26320083 | — | — | 0.951 |
| 3 | SRR26320081 | — | — | 0.948 |
| 4 | SRR13311179 | — | — | 0.937 |
| 5 | ERR4976608 | — | D | 0.929 |
| 6 | SRR4195666 | — | — | 0.929 |
| 7 | sclc265549_S73.txt | — | cohortMD1 | 0.928 |
| 8 | SRR8942981 | — | — | 0.927 |
| 9 | ERR4976613 | — | D | 0.926 |
| 10 | c7d31245-5d71-4a23-8a33-4f83c4718e20 | — | — | 0.925 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 4 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| PANCREAS_BETA_CELLS | 0.360 | Cobimetinib | — uncovered |
| SPERMATOGENESIS | 0.170 | Inavolisib | — uncovered |
| KRAS_SIGNALING_DN | 0.110 | Remibrutinib | — uncovered |
| HEDGEHOG_SIGNALING | 0.050 | Inavolisib | — uncovered |