SRR1445149
GTEX
Clinical attributes
From the source cohort, normalized into canonical keys plus the project's native columns.
- cancer_type
- GTEX
- cancer_type_detailed
- —
- subtype
- —
- cancer_type
- GTEX
- sex
- Male
GSVA pathway preview (50 Hallmark scores)
Top 10 most elevated and top 10 most suppressed Hallmark pathways for this sample.
Top 10 elevated
- KRAS_SIGNALING_DN+0.355
- MYOGENESIS+0.292
- APICAL_SURFACE+0.184
- HEDGEHOG_SIGNALING+0.183
- SPERMATOGENESIS+0.164
- PANCREAS_BETA_CELLS+0.158
- APICAL_JUNCTION+0.089
- MITOTIC_SPINDLE+0.011
- UV_RESPONSE_DN-0.036
- FATTY_ACID_METABOLISM-0.060
Top 10 suppressed
- IL6_JAK_STAT3_SIGNALING-0.601
- MYC_TARGETS_V1-0.561
- INTERFERON_GAMMA_RESPONSE-0.517
- INTERFERON_ALPHA_RESPONSE-0.489
- E2F_TARGETS-0.468
- TNFA_SIGNALING_VIA_NFKB-0.463
- ALLOGRAFT_REJECTION-0.453
- UNFOLDED_PROTEIN_RESPONSE-0.446
- COMPLEMENT-0.406
- INFLAMMATORY_RESPONSE-0.405
Patient twins — nearest pathway neighbors
10 samples closest to this one in 50-dim pathway space, drawn from the Pathway Atlas. Cosine similarity = 1 means identical pathway state.
10 twins match this tumor's tissue · 0 come from a different tissue of origin
| # | Sample | Cancer type | Subtype | cos similarity |
|---|---|---|---|---|
| 1 | SRR1404640 | GTEX | — | 0.982 |
| 2 | SRR1362532 | GTEX | — | 0.975 |
| 3 | SRR1335400 | GTEX | — | 0.967 |
| 4 | SRR1320093 | GTEX | — | 0.966 |
| 5 | SRR1474951 | GTEX | — | 0.964 |
| 6 | SRR1392985 | GTEX | — | 0.961 |
| 7 | SRR1311794 | GTEX | — | 0.960 |
| 8 | SRR1334564 | GTEX | — | 0.958 |
| 9 | SRR1480988 | GTEX | — | 0.958 |
| 10 | SRR1337564 | GTEX | — | 0.955 |
Per-pathway drug coverage
For each elevated pathway in this tumor, the best-reversing drug across the catalog. Uncovered pathways = unmet need at pathway level for this one patient.
0 of 8 elevated pathways have at least one drug that meaningfully reverses them.
| Pathway (elevated) | tumor score | Best drug | reversal magnitude |
|---|---|---|---|
| KRAS_SIGNALING_DN | 0.355 | Remibrutinib | — uncovered |
| MYOGENESIS | 0.292 | Inavolisib | — uncovered |
| APICAL_SURFACE | 0.184 | Temsirolimus | — uncovered |
| HEDGEHOG_SIGNALING | 0.183 | Inavolisib | — uncovered |
| SPERMATOGENESIS | 0.164 | Inavolisib | — uncovered |
| PANCREAS_BETA_CELLS | 0.158 | Cobimetinib | — uncovered |
| APICAL_JUNCTION | 0.089 | Inavolisib | — uncovered |
| MITOTIC_SPINDLE | 0.011 | Inavolisib | — uncovered |