KIRhub 2.0· v2

Encorafenib

9ddf32c7-bd2b-5c15-b81b-eed1807a1094 · FDA Approved · targets BRAF

Encorafenib

MeasuredReference

Encorafenib targets RAF1, BRAF, IRAK1. Strongest hallmark effect: evading apoptosis.

Primary targets

RAF1 BRAF IRAK1 ARAF LIMK2

Top hallmarks

evading apoptosis2.6k
tumor promoting inflammation2.6k
proliferation2.6k

Top pathways disrupted

g2m checkpoint4.9k
e2f targets4.6k
apoptosis4.5k

Resistance landscape — Encorafenib

MeasuredReference

10 known oncogenic variants exist on Encorafenib's top targets — see detail for inhibition impact.

RAF1 1 known variant
- RAF1 (R391W)
BRAF 9 known variants

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