Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
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RAF1

RBC: RAF1 · Substrate: MEK1 (K97R) ·

Top inhibitors

MeasuredDerived
DrugInhibition %Gini
Ripretinib100.00.67
Apatinib100.00.70
Sorafenib100.00.78
Ponatinib100.00.53
Regorafenib99.90.72
Upadacitinib99.90.66
Dabrafenib99.80.63
Umbralisib99.80.67
Encorafenib99.70.76
Nilotinib98.30.77
Rabusertib95.60.69
Pazopanib95.50.67
Vemurafenib95.20.60
Dasatinib74.30.70
Imatinib74.00.72

Known variants

Cancer associations

MutationCancer typeOrganSource
R391Wcarcinoid-endocrine_tumour_lungLunghttps://doi.org/10.1093/nar/gkaa945
R391Wlymphoid_neoplasm_haematopoietic_and_lymphoid_tissueBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
R391Wmalignant_melanoma_skinSkinhttps://doi.org/10.1093/nar/gkaa945
R391WCLLE-ESBlood/Lymphatic Systemhttps://doi.org/10.1093/nar/gkaa945
R391WKIRP-USKidneyhttps://doi.org/10.1093/nar/gkaa945
R391WKIRPKidneyhttps://doi.org/10.1093/nar/gkaa945
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