Research Use Only. KIRhub outputs are computational research artifacts. They are not validated for clinical decision-making, diagnosis, or treatment.
KIRhub 2.0· v2
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Alpelisib

ba609854-86b5-55c9-9a10-2500655fb473 · FDA Approved · targets PI3K

Alpelisib

MeasuredReference

Alpelisib targets RET, NTRK2, NTRK3.

Primary targets

RETNTRK2NTRK3FGFR2FGFR1

Top hallmarks

No hallmark data.

Top pathways disrupted

  • pi3k akt mtor signaling7.2k
  • apical junction6.3k
  • allograft rejection6.2k

Resistance landscape — Alpelisib

MeasuredReference

10 known oncogenic variants exist on Alpelisib's top targets — see detail for inhibition impact.

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