Rational drug combinations

DerivedModeled

3-drug combinations chosen by greedy max-coverage in pathway space. The chosen drugs have the LOWEST pairwise cosine (most orthogonal mechanisms) and together cover the largest fraction of cancer pathway perturbation. Try k=3 · k=4 · k=5.

Rank	Drugs	Pathway coverage	Mean pairwise cos
1	Pacritinib + Midostaurin + Defactinib	3.1%	1.00
2	Ponatinib + Pacritinib + Midostaurin	3.1%	0.99
3	Brigatinib + Pacritinib + Midostaurin	3.1%	0.99
4	Abemaciclib + Pacritinib + Midostaurin	3.1%	0.97
5	Bosutinib + Pacritinib + Midostaurin	3.1%	0.99
6	Gilteritinib + Pacritinib + Midostaurin	3.1%	0.99
7	Nintedanib + Pacritinib + Midostaurin	3.1%	0.99
8	Repotrectinib + Pacritinib + Midostaurin	3.1%	0.99
9	Pralsetinib + Pacritinib + Midostaurin	3.1%	0.99
10	Sunitinib + Pacritinib + Midostaurin	3.1%	1.00
11	Neratinib + Pacritinib + Midostaurin	3.1%	1.00
12	Dasatinib + Pacritinib + Midostaurin	3.1%	0.99
13	Fedratinib + Pacritinib + Midostaurin	3.1%	0.99
14	Fostamatinib + Pacritinib + Midostaurin	3.1%	0.99
15	Vemurafenib + Pacritinib + Midostaurin	3.1%	1.00
16	Ripretinib + Pacritinib + Midostaurin	3.1%	0.99
17	Canertinib + Pacritinib + Midostaurin	3.1%	0.99
18	Crizotinib + Pacritinib + Midostaurin	3.1%	0.99
19	Alectinib + Pacritinib + Midostaurin	3.1%	0.99
20	Entrectinib + Pacritinib + Midostaurin	3.1%	0.98
21	Tivozanib + Pacritinib + Midostaurin	3.1%	0.98
22	Vandetanib + Pacritinib + Midostaurin	3.1%	0.98
23	Selpercatinib + Pacritinib + Midostaurin	3.1%	0.99
24	Ibrutinib + Pacritinib + Midostaurin	3.1%	0.98
25	Dacomitinib + Pacritinib + Midostaurin	3.1%	0.99
26	Dabrafenib + Pacritinib + Midostaurin	3.1%	1.00
27	Erdafitinib + Pacritinib + Midostaurin	3.1%	0.99
28	Pazopanib + Pacritinib + Midostaurin	3.1%	0.99

Next steps

Cross-reference with the existing combination recommender (which scores by target overlap, not pathway coverage) to see which combos appear in both lists — those are the highest-confidence picks.