Rational drug combinations

DerivedModeled

4-drug combinations chosen by greedy max-coverage in pathway space. The chosen drugs have the LOWEST pairwise cosine (most orthogonal mechanisms) and together cover the largest fraction of cancer pathway perturbation. Try k=3 · k=4 · k=5.

Rank	Drugs	Pathway coverage	Mean pairwise cos
1	Pacritinib + Midostaurin + Defactinib + Ponatinib	3.1%	0.99
2	Brigatinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
3	Bosutinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
4	Abemaciclib + Pacritinib + Midostaurin + Defactinib	3.1%	0.98
5	Gilteritinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
6	Nintedanib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
7	Repotrectinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
8	Pralsetinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
9	Sunitinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
10	Neratinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
11	Dasatinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
12	Fedratinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
13	Fostamatinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
14	Vemurafenib + Pacritinib + Midostaurin + Defactinib	3.1%	1.00
15	Ripretinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
16	Canertinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
17	Crizotinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
18	Alectinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
19	Entrectinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.98
20	Tivozanib + Pacritinib + Midostaurin + Defactinib	3.1%	0.98
21	Vandetanib + Pacritinib + Midostaurin + Defactinib	3.1%	0.98
22	Selpercatinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
23	Ibrutinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.98
24	Dacomitinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
25	Dabrafenib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
26	Erdafitinib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99
27	Pazopanib + Pacritinib + Midostaurin + Defactinib	3.1%	0.99

Next steps

Cross-reference with the existing combination recommender (which scores by target overlap, not pathway coverage) to see which combos appear in both lists — those are the highest-confidence picks.