UniProt Q16566 · PDB · AlphaFold · Substrate: ZIPtide + Ca-CaM* · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abrocitinib | 24.5% | 75.5% | 99.50 | 0.581 |
| 2 | Zanubrutinib | 17.9% | 82.1% | 98.24 | 0.788 |
| 3 | Ripretinib | 15.5% | 84.5% | 92.95 | 0.674 |
| 4 | Pralsetinib | 14.2% | 85.8% | 93.43 | 0.643 |
| 5 | Tucatinib | 14.1% | 85.9% | 99.75 | 0.652 |
| 6 | Apatinib | 13.1% | 86.9% | 97.73 | 0.704 |
| 7 | Tepotinib | 12.7% | 87.3% | 99.75 | 0.727 |
| 8 | Mitapivat | 12.5% | 87.5% | 100.00 | 0.625 |
| 9 | Avapritinib | 12.5% | 87.5% | 97.73 | 0.644 |
| 10 | Sunitinib | 11.3% | 88.7% | 91.73 | 0.524 |
| 11 | Futibatinib | 10.9% | 89.1% | 98.48 | 0.718 |
| 12 | Palbociclib | 10.8% | 89.2% | 98.75 | 0.673 |
| 13 | Fedratinib | 10.7% | 89.3% | 96.21 | 0.576 |
| 14 | Sorafenib | 10.5% | 89.5% | 96.72 | 0.776 |
| 15 | Selumetinib | 10.2% | 89.8% | 100.00 | 0.640 |
| 16 | Leniolisib | 10.1% | 89.9% | 100.00 | 0.604 |
| 17 | Ponatinib | 10.0% | 90.0% | 78.23 | 0.534 |
| 18 | Asciminib | 9.8% | 90.2% | 100.00 | 0.602 |
| 19 | Paxalisib | 9.4% | 90.6% | 99.75 | 0.609 |
| 20 | Abemaciclib | 9.1% | 90.9% | 91.48 | 0.563 |
Paralog block
No paralog group registered for this kinase.
EMT expression
- Mesenchymal log2(TPM+1): 1.85
- Epithelial log2(TPM+1): 0.79
- Fold change: 1.06
- Status: Upregulated
Selectivity landscape vs inhibition on CAMK4
Each point is one of the 92 approved drugs; color = inhibition % on CAMK4.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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