CDK2/CCNA1(CDK2/cyclin A1)
Sign in to save this workspaceUniProt CDK2: P24941; cyclin A1:P78396 · PDB · AlphaFold (P24941), AlphaFold (P78396) · Substrate: RB Protein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 94.0% | 6.0% | 91.48 | 0.563 |
| 2 | Defactinib | 80.9% | 19.1% | 92.68 | 0.450 |
| 3 | Pralsetinib | 48.1% | 51.9% | 93.43 | 0.643 |
| 4 | Vemurafenib | 47.3% | 52.7% | 96.49 | 0.598 |
| 5 | Midostaurin | 45.7% | 54.3% | 78.64 | 0.500 |
| 6 | Palbociclib | 42.7% | 57.3% | 98.75 | 0.673 |
| 7 | Pacritinib | 33.4% | 66.6% | 88.64 | 0.452 |
| 8 | Pemigatinib | 30.8% | 69.2% | 98.23 | 0.718 |
| 9 | Brigatinib | 29.2% | 70.8% | 82.96 | 0.513 |
| 10 | Baricitinib | 25.6% | 74.4% | 97.99 | 0.616 |
| 11 | Fostamatinib | 24.5% | 75.5% | 96.74 | 0.613 |
| 12 | Repotrectinib | 22.2% | 77.8% | 84.21 | 0.608 |
| 13 | Lorlatinib | 21.7% | 78.3% | 97.24 | 0.694 |
| 14 | Encorafenib | 21.2% | 78.8% | 98.50 | 0.755 |
| 15 | Dabrafenib | 19.7% | 80.3% | 94.74 | 0.633 |
| 16 | Axitinib | 19.5% | 80.5% | 93.23 | 0.688 |
| 17 | Ibrutinib | 18.3% | 81.7% | 94.74 | 0.723 |
| 18 | Duvelisib | 18.2% | 81.8% | 100.00 | 0.716 |
| 19 | Capivasertib | 18.1% | 81.9% | 96.48 | 0.644 |
| 20 | Ribociclib | 18.1% | 81.9% | 99.25 | 0.729 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK2/CCNA1
Each point is one of the 92 approved drugs; color = inhibition % on CDK2/CCNA1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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