CDK2/CCNO(CDK2/cyclin O)
Sign in to save this workspaceUniProt CDK2: P24941; cyclin O: P22674 · PDB · AlphaFold (P24941), AlphaFold (P22674) · Substrate: Histone H1 · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 92.4% | 7.6% | 91.48 | 0.563 |
| 2 | Defactinib | 85.8% | 14.2% | 92.68 | 0.450 |
| 3 | Palbociclib | 65.7% | 34.3% | 98.75 | 0.673 |
| 4 | Vemurafenib | 45.7% | 54.3% | 96.49 | 0.598 |
| 5 | Pacritinib | 42.9% | 57.1% | 88.64 | 0.452 |
| 6 | Pralsetinib | 37.3% | 62.7% | 93.43 | 0.643 |
| 7 | Midostaurin | 35.0% | 65.0% | 78.64 | 0.500 |
| 8 | Sunitinib | 26.9% | 73.1% | 91.73 | 0.524 |
| 9 | Brigatinib | 25.6% | 74.4% | 82.96 | 0.513 |
| 10 | Repotrectinib | 22.6% | 77.4% | 84.21 | 0.608 |
| 11 | Gilteritinib | 18.4% | 81.6% | 88.97 | 0.506 |
| 12 | Pemigatinib | 17.5% | 82.5% | 98.23 | 0.718 |
| 13 | Crizotinib | 17.2% | 82.8% | 91.39 | 0.581 |
| 14 | Ponatinib | 15.4% | 84.6% | 78.23 | 0.534 |
| 15 | Axitinib | 10.8% | 89.2% | 93.23 | 0.688 |
| 16 | Avapritinib | 10.3% | 89.7% | 97.73 | 0.644 |
| 17 | Acalabrutinib | 10.1% | 89.9% | 99.50 | 0.670 |
| 18 | Upadacitinib | 10.0% | 90.0% | 97.98 | 0.663 |
| 19 | Dabrafenib | 9.9% | 90.1% | 94.74 | 0.633 |
| 20 | Ceritinib | 9.1% | 90.9% | 95.44 | 0.618 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK2/CCNO
Each point is one of the 92 approved drugs; color = inhibition % on CDK2/CCNO.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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