CDK4/CCND1(CDK4/cyclin D1)
Sign in to save this workspaceUniProt CDK4: P11802; Cyclin D1: P24385 · PDB · AlphaFold (P11802), AlphaFold (P24385) · Substrate: RB Protein · Clone: full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 99.2% | 0.8% | 91.48 | 0.563 |
| 2 | Palbociclib | 99.0% | 1.0% | 98.75 | 0.673 |
| 3 | Ribociclib | 94.7% | 5.3% | 99.25 | 0.729 |
| 4 | Pacritinib | 86.2% | 13.8% | 88.64 | 0.452 |
| 5 | Dabrafenib | 56.7% | 43.3% | 94.74 | 0.633 |
| 6 | Defactinib | 37.8% | 62.3% | 92.68 | 0.450 |
| 7 | Brigatinib | 34.8% | 65.2% | 82.96 | 0.513 |
| 8 | Ponatinib | 28.3% | 71.7% | 78.23 | 0.534 |
| 9 | Gilteritinib | 25.1% | 74.9% | 88.97 | 0.506 |
| 10 | Fedratinib | 23.8% | 76.2% | 96.21 | 0.576 |
| 11 | Pirtobrutinib | 22.2% | 77.8% | 99.49 | 0.656 |
| 12 | Pemigatinib | 20.6% | 79.4% | 98.23 | 0.718 |
| 13 | Avapritinib | 19.7% | 80.3% | 97.73 | 0.644 |
| 14 | Crizotinib | 17.7% | 82.3% | 91.39 | 0.581 |
| 15 | Infigratinib | 16.9% | 83.1% | 98.24 | 0.710 |
| 16 | Tucatinib | 16.4% | 83.6% | 99.75 | 0.652 |
| 17 | Zanubrutinib | 13.5% | 86.5% | 98.24 | 0.788 |
| 18 | Sunitinib | 13.4% | 86.6% | 91.73 | 0.524 |
| 19 | Ceritinib | 13.3% | 86.7% | 95.44 | 0.618 |
| 20 | Abrocitinib | 12.0% | 88.0% | 99.50 | 0.581 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK4/CCND1
Each point is one of the 92 approved drugs; color = inhibition % on CDK4/CCND1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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