CDK6/CCND1(CDK6/cyclin D1)
Sign in to save this workspaceUniProt CDK6: Q00534; Cyclin D1: P24385 · PDB · AlphaFold (Q00534), AlphaFold (P24385) · Substrate: RB Protein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 99.3% | 0.7% | 91.48 | 0.563 |
| 2 | Palbociclib | 98.6% | 1.4% | 98.75 | 0.673 |
| 3 | Ribociclib | 95.3% | 4.7% | 99.25 | 0.729 |
| 4 | Pacritinib | 69.2% | 30.9% | 88.64 | 0.452 |
| 5 | Defactinib | 56.9% | 43.1% | 92.68 | 0.450 |
| 6 | Nintedanib | 51.0% | 49.0% | 90.23 | 0.608 |
| 7 | Gilteritinib | 41.1% | 58.9% | 88.97 | 0.506 |
| 8 | Sunitinib | 40.2% | 59.8% | 91.73 | 0.524 |
| 9 | Brigatinib | 37.1% | 62.9% | 82.96 | 0.513 |
| 10 | Vemurafenib | 26.9% | 73.1% | 96.49 | 0.598 |
| 11 | Infigratinib | 23.7% | 76.3% | 98.24 | 0.710 |
| 12 | Ponatinib | 15.3% | 84.7% | 78.23 | 0.534 |
| 13 | Dabrafenib | 14.6% | 85.4% | 94.74 | 0.633 |
| 14 | Neratinib | 12.6% | 87.4% | 93.18 | 0.597 |
| 15 | Lazertinib | 11.2% | 88.8% | 97.47 | 0.674 |
| 16 | Gedatolisib | 10.7% | 89.3% | 99.75 | 0.611 |
| 17 | Baricitinib | 10.7% | 89.3% | 97.99 | 0.616 |
| 18 | Avapritinib | 10.1% | 89.9% | 97.73 | 0.644 |
| 19 | Sirolimus | 9.0% | 91.0% | 100.00 | 0.708 |
| 20 | Tepotinib | 8.4% | 91.6% | 99.75 | 0.727 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK6/CCND1
Each point is one of the 92 approved drugs; color = inhibition % on CDK6/CCND1.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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