CDK6/CCND2(CDK6/cyclin D2)
Sign in to save this workspaceUniProt CDK6: Q00534; Cyclin D2: P30279 · PDB · AlphaFold (Q00534), AlphaFold (P30279) · Substrate: RB Protein · Clone: full-length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Ponatinib | 53.2% | 46.8% | 78.23 | 0.534 |
| 2 | Pacritinib | 51.8% | 48.2% | 88.64 | 0.452 |
| 3 | Defactinib | 39.1% | 60.9% | 92.68 | 0.450 |
| 4 | Pemigatinib | 34.2% | 65.8% | 98.23 | 0.718 |
| 5 | Infigratinib | 25.3% | 74.7% | 98.24 | 0.710 |
| 6 | Pirtobrutinib | 14.2% | 85.8% | 99.49 | 0.656 |
| 7 | Neratinib | 11.5% | 88.5% | 93.18 | 0.597 |
| 8 | Gedatolisib | 9.8% | 90.2% | 99.75 | 0.611 |
| 9 | Zanubrutinib | 9.1% | 90.9% | 98.24 | 0.788 |
| 10 | Canertinib | 8.3% | 91.7% | 96.49 | 0.671 |
| 11 | Sorafenib | 8.0% | 92.0% | 96.72 | 0.776 |
| 12 | Apatinib | 7.7% | 92.3% | 97.73 | 0.704 |
| 13 | Capmatinib | 7.3% | 92.7% | 99.75 | 0.582 |
| 14 | Lazertinib | 7.0% | 93.0% | 97.47 | 0.674 |
| 15 | Umbralisib | 6.2% | 93.8% | 98.74 | 0.670 |
| 16 | Crizotinib | 5.9% | 94.1% | 91.39 | 0.581 |
| 17 | Repotrectinib | 5.7% | 94.3% | 84.21 | 0.608 |
| 18 | Darovasertib | 5.7% | 94.3% | 96.99 | 0.719 |
| 19 | Tivozanib | 5.5% | 94.5% | 92.42 | 0.673 |
| 20 | Mobocertinib | 5.3% | 94.7% | 97.22 | 0.757 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK6/CCND2
Each point is one of the 92 approved drugs; color = inhibition % on CDK6/CCND2.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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