CDK6/CCND3(CDK6/cyclin D3)
Sign in to save this workspaceUniProt CDK6: Q00534; Cyclin D3: P30281 · PDB · AlphaFold (Q00534), AlphaFold (P30281) · Substrate: RB Protein · Clone: full length / full length
Top inhibitors
| # | Drug | Inhibition | Residual | KISS | Gini |
|---|---|---|---|---|---|
| 1 | Abemaciclib | 98.7% | 1.3% | 91.48 | 0.563 |
| 2 | Palbociclib | 98.5% | 1.5% | 98.75 | 0.673 |
| 3 | Pacritinib | 78.0% | 22.0% | 88.64 | 0.452 |
| 4 | Sunitinib | 75.9% | 24.1% | 91.73 | 0.524 |
| 5 | Ribociclib | 73.3% | 26.7% | 99.25 | 0.729 |
| 6 | Dabrafenib | 66.9% | 33.1% | 94.74 | 0.633 |
| 7 | Pemigatinib | 63.3% | 36.7% | 98.23 | 0.718 |
| 8 | Defactinib | 49.0% | 51.0% | 92.68 | 0.450 |
| 9 | Ponatinib | 45.1% | 54.9% | 78.23 | 0.534 |
| 10 | Crizotinib | 36.3% | 63.7% | 91.39 | 0.581 |
| 11 | Brigatinib | 27.8% | 72.2% | 82.96 | 0.513 |
| 12 | Gilteritinib | 24.8% | 75.2% | 88.97 | 0.506 |
| 13 | Fedratinib | 24.2% | 75.8% | 96.21 | 0.576 |
| 14 | Trametinib | 23.3% | 76.7% | 99.50 | 0.718 |
| 15 | Vemurafenib | 20.1% | 79.9% | 96.49 | 0.598 |
| 16 | Midostaurin | 18.2% | 81.8% | 78.64 | 0.500 |
| 17 | Fostamatinib | 18.0% | 82.0% | 96.74 | 0.613 |
| 18 | Infigratinib | 16.7% | 83.3% | 98.24 | 0.710 |
| 19 | Dacomitinib | 16.6% | 83.4% | 97.99 | 0.664 |
| 20 | Ibrutinib | 15.3% | 84.7% | 94.74 | 0.723 |
Paralog block
No paralog group registered for this kinase.
EMT expression
Not in the EMT expression panel.
Selectivity landscape vs inhibition on CDK6/CCND3
Each point is one of the 92 approved drugs; color = inhibition % on CDK6/CCND3.
3D structure
Embedded NGL viewer pulls a representative PDB entry (or AlphaFold model if no experimental structure is registered). Heavy bundle — loaded only on demand.
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